Modeling Diet-Induced NAFLD and NASH in Rats: A Comprehensive Review

被引：39

作者：

Carreres, Lydie ^{[1
,2
]}

Jilkova, Zuzana Macek ^{[1
,2
]}

Vial, Guillaume ^{[2
,3
]}

Marche, Patrice N. ^{[1
,2
]}

Decaens, Thomas ^{[1
,2
,4
]}

Lerat, Herve ^{[1
,2
,5
]}

机构：

[1] CNRS 5309, Inst Adv Biosci, Res Ctr, INSERM,U 1209, F-38700 La Tronche, France

[2] Univ Grenoble Alpes, F-38000 Grenoble, France

[3] INSERM, Hypoxia PathoPhysiol HP2, U 1300, F-38000 Grenoble, France

[4] CHU Grenoble Alpes, Serv Hepatogastroenterol, Pole Digidune, F-38700 La Tronche, France

[5] CNRS, Unite Mixte Serv UGA hTAG, INSERM, UAR 2019,US 046, F-38700 La Tronche, France

来源：

BIOMEDICINES | 2021年 / 9卷 / 04期

关键词：

NAFLD; NASH; fibrosis; metabolic syndrome; obesity; rats; diet; NONALCOHOLIC FATTY LIVER; METABOLIC SYNDROME; NUTRITIONAL MODEL; HEPATOCELLULAR-CARCINOMA; INSULIN-RESISTANCE; HEPATIC STEATOSIS; SCORING SYSTEM; SHIFT WORK; BILE-ACID; STEATOHEPATITIS;

D O I：

10.3390/biomedicines9040378

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, characterized by hepatic steatosis without any alcohol abuse. As the prevalence of NAFLD is rapidly increasing worldwide, important research activity is being dedicated to deciphering the underlying molecular mechanisms in order to define new therapeutic targets. To investigate these pathways and validate preclinical study, reliable, simple and reproducible tools are needed. For that purpose, animal models, more precisely, diet-induced NAFLD and nonalcoholic steatohepatitis (NASH) models, were developed to mimic the human disease. In this review, we focus on rat models, especially in the current investigation of the establishment of the dietary model of NAFLD and NASH in this species, compiling the different dietary compositions and their impact on histological outcomes and metabolic injuries, as well as external factors influencing the course of liver pathogenesis.

引用

页数：16

共 98 条

[1] Increased Fructose Consumption Is Associated with Fibrosis Severity in Patients with Nonalcoholic Fatty Liver Disease [J].