Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes

被引：105

作者：

Jahanban-Esfahlan, Rana ^{[4
]}

Mehrzadi, Saeed ^{[5
]}

Reiter, Russel J. ^{[6
]}

Seidi, Khaled ^{[7
]}

Majidinia, Maryam ^{[8
]}

Baghi, Hossein Bannazadeh ^{[9
]}

Khatami, Nasrin ^{[10
]}

Yousefi, Bahman ^{[1
,11
,12
]}

Sadeghpour, Alireza ^{[2
,3
]}

机构：

[1] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Dept Orthopaed Surg, Sch Med, Tabriz, Iran

[3] Tabriz Univ Med Sci, Shohada Educ Hosp, Tabriz, Iran

[4] Tabriz Univ ofMed Sci, Fac Adv Med Sci, Dept Med Biotechnol, Tabriz, Iran

[5] Iran Univ Med Sci, Razi Drug Res Ctr, Tehran, Iran

[6] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA

[7] Tabriz Univ ofMed Sci, Immunol Res Ctr, Tabriz, Iran

[8] Urmia Univ Med Sci, Solid Tumor Res Ctr, Orumiyeh, Iran

[9] Tabriz Univ Med Sci, Infect & Trop Dis Res Ctr, Tabriz, Iran

[10] Tabriz Univ Med Sci, Students Res Comm, Tabriz, Iran

[11] Tabriz Univ Med Sci, Mol Targeting Therapy Res Grp, Fac Med, Tabriz, Iran

[12] Tabriz Univ Med Sci, Dept Clin Biochem & Lab Med, Fac Med, Tabriz, Iran

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2018年 / 175卷 / 16期

关键词：

NF-KAPPA-B; COLLAGEN-INDUCED ARTHRITIS; MESENCHYMAL STEM-CELLS; CONCISE GUIDE; EXAGGERATES DEVELOPMENT; SYNOVIAL MACROPHAGES; EXPRESSION; CARTILAGE; PHARMACOLOGY; TRANSCRIPTION;

D O I：

10.1111/bph.13898

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rheumatoid arthritis (RA) and osteoarthritis (OA) are the two most prevalent joint diseases. A such, they are important causes of pain and disability in a substantial proportion of the human population. A common characteristic of these diseases is the erosion of articular cartilage and consequently joint dysfunction. Melatonin has been proposed as a link between circadian rhythms and joint diseases including RA and OA. This hormone exerts a diversity of regulatory actions through binding to specific receptors and intracellular targets as well as having receptor-independent actions as a free radical scavenger. Cytoprotective effects of melatonin involve a myriad of prominent receptor-mediated pathways/molecules associated with inflammation, of which the role of omnipresent NF-kappa B signalling is crucial. Likewise, disturbance of circadian timekeeping is closely involved in the aetiology of inflammatory arthritis. Melatonin is shown to stimulate cartilage destruction/regeneration through direct/indirect modulation of the expression of the main circadian clock genes, such as BMAL, CRY and/or DEC2. In the current article, we review the effects of melatonin on RA and OA, focusing on its ability to regulate inflammatory pathways and circadian rhythms. We also review the possible protective effects of melatonin on RA and OA pathogenesis.

引用

页码：3230 / 3238

页数：9

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