Pre-mRNA mis-splicing of sarcomeric genes in heart failure

被引：26
作者：
Zhu, Chaoqun [1 ]
Chen, Zhilong [1 ,2 ]
Guo, Wei [1 ]
机构：
[1] Univ Wyoming, Coll Agr & Nat Resources, Anim Sci, Laramie, WY 82071 USA
[2] Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2017年 / 1863卷 / 08期
关键词：
Alternative splicing; Sarcomeric genes; Splicing factor; Heart failure; TROPONIN-T ISOFORMS; DILATED CARDIOMYOPATHY; TITIN ISOFORM; ALPHA-TROPOMYOSIN; SKELETAL-MUSCLE; CA2+ SENSITIVITY; OLIGONUCLEOTIDE COMPLEMENTARY; MYOCARDIAL STIFFNESS; REGULATORY ELEMENTS; SPLICING REGULATION;
D O I：
10.1016/j.bbadis.2016.11.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single gene in the genome, and mainly contributes to protein diversity in eulcaryotic organisms. Alternative splicing is commonly governed by RNA binding proteins to meet the ever-changing demands of the cell. However, the mis-splicing may lead to human diseases. In the heart of human, mis-regulation of alternative splicing has been associated with heart failure. In this short review, we focus on alternative splicing of sarcomeric genes and review mis-splicing related heart failure with relatively well studied Sarcomeric genes and splicing mechanisms with identified regulatory factors. The perspective of alternative splicing based therapeutic strategies in heart failure has also been discussed. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：2056 / 2063
页数：8
相关论文
共 106 条
  • [61] RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-rnRNA processing
    Maatz, Henrike
    Jens, Marvin
    Liss, Martin
    Schafer, Sebastian
    Heinig, Matthias
    Kirchner, Marieluise
    Adami, Eleonora
    Rintisch, Carola
    Dauksaite, Vita
    Radke, Michael H.
    Selbach, Matthias
    Barton, Paul J. R.
    Cook, Stuart A.
    Rajewsky, Nikolaus
    Gotthardt, Michael
    Landthaler, Markus
    Hubner, Norbert
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (08) : 3419 - 3430
  • [62] Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts
    Makarenko, I
    Opitz, CA
    Leake, MC
    Neagoe, C
    Kulke, M
    Gwathmey, JK
    del Monte, F
    Hajjar, RJ
    Linke, WA
    [J]. CIRCULATION RESEARCH, 2004, 95 (07) : 708 - 716
  • [63] APPRIS: annotation of principal and alternative splice isoforms
    Manuel Rodriguez, Jose
    Maietta, Paolo
    Ezkurdia, Iakes
    Pietrelli, Alessandro
    Wesselink, Jan-Jaap
    Lopez, Gonzalo
    Valencia, Alfonso
    Tress, Michael L.
    [J]. NUCLEIC ACIDS RESEARCH, 2013, 41 (D1) : D110 - D117
  • [64] MARUYAMA K, 1977, J BIOCHEM, V82, P347
  • [65] Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice
    Merki, Esther
    Graham, Mark J.
    Mullick, Adam E.
    Miller, Elizabeth R.
    Crooke, Rosanne M.
    Pitas, Robert E.
    Witztum, Joseph L.
    Tsimikas, Sotirios
    [J]. CIRCULATION, 2008, 118 (07) : 743 - 753
  • [66] Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole
    Methawasin, Mei
    Hutchinson, Kirk R.
    Lee, Eun-Jeong
    Smith, John E., III
    Saripalli, Chandra
    Hidalgo, Carlos G.
    Ottenheijm, Coen A. C.
    Granzier, Henk
    [J]. CIRCULATION, 2014, 129 (19) : 1924 - 1936
  • [67] Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy
    Millat, Gilles
    Bouvagnet, Patrice
    Chevalier, Philippe
    Sebbag, Laurent
    Dulac, Arnaud
    Dauphin, Claire
    Jouk, Pierre-Simon
    Delrue, Marie-Ange
    Thambo, Jean-Benoit
    Le Metayer, Philippe
    Seronde, Marie-France
    Faivre, Laurence
    Eicher, Jean-Christophe
    Rousson, Robert
    [J]. EUROPEAN JOURNAL OF MEDICAL GENETICS, 2011, 54 (06) : E570 - E575
  • [68] DEVELOPMENTAL ANALYSIS OF TROPOMYOSIN GENE-EXPRESSION IN EMBRYONIC STEM-CELLS AND MOUSE EMBRYOS
    MUTHUCHAMY, M
    PAJAK, L
    HOWLES, P
    DOETSCHMAN, T
    WIECZOREK, DF
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (06) : 3311 - 3323
  • [69] Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy
    Nagueh, SF
    Shah, G
    Wu, YM
    Torre-Amione, G
    King, NMP
    Lahmers, S
    Witt, CC
    Becker, K
    Labeit, S
    Granzier, HL
    [J]. CIRCULATION, 2004, 110 (02) : 155 - 162
  • [70] Gigantic variety: expression patterns of titin isoforms in striated muscles and consequences for myofibrillar passive stiffness
    Neagoe, C
    Opitz, CA
    Makarenko, I
    Linke, WA
    [J]. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 2003, 24 (2-3) : 175 - 189
234567891011