Pre-mRNA mis-splicing of sarcomeric genes in heart failure

被引：26
作者：
Zhu, Chaoqun [1 ]
Chen, Zhilong [1 ,2 ]
Guo, Wei [1 ]
机构：
[1] Univ Wyoming, Coll Agr & Nat Resources, Anim Sci, Laramie, WY 82071 USA
[2] Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2017年 / 1863卷 / 08期
关键词：
Alternative splicing; Sarcomeric genes; Splicing factor; Heart failure; TROPONIN-T ISOFORMS; DILATED CARDIOMYOPATHY; TITIN ISOFORM; ALPHA-TROPOMYOSIN; SKELETAL-MUSCLE; CA2+ SENSITIVITY; OLIGONUCLEOTIDE COMPLEMENTARY; MYOCARDIAL STIFFNESS; REGULATORY ELEMENTS; SPLICING REGULATION;
D O I：
10.1016/j.bbadis.2016.11.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single gene in the genome, and mainly contributes to protein diversity in eulcaryotic organisms. Alternative splicing is commonly governed by RNA binding proteins to meet the ever-changing demands of the cell. However, the mis-splicing may lead to human diseases. In the heart of human, mis-regulation of alternative splicing has been associated with heart failure. In this short review, we focus on alternative splicing of sarcomeric genes and review mis-splicing related heart failure with relatively well studied Sarcomeric genes and splicing mechanisms with identified regulatory factors. The perspective of alternative splicing based therapeutic strategies in heart failure has also been discussed. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：2056 / 2063
页数：8
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