Quantitative Three-Dimensional Gait Evaluation in Patients With Glucose Transporter 1 Deficiency Syndrome

被引:2
作者
Suzuki, Takeshi [1 ]
Ito, Yuji [1 ,2 ,8 ]
Ito, Tadashi [3 ]
Kidokoro, Hiroyuki [1 ]
Noritake, Koji [4 ]
Hattori, Ayako [5 ]
Nabatame, Shin [6 ]
Natsume, Jun [1 ,7 ]
机构
[1] Nagoya Univ, Dept Pediat, Grad Sch Med, Nagoya, Japan
[2] Aichi Prefectural Mikawa Aoitori Med & Rehabil Ctr, Dept Pediat, Okazaki, Japan
[3] Aichi Prefectural Mikawa Aoitori Med & Rehabil Ctr, Three-Dimens Mot Anal Room, Okazaki, Japan
[4] Aichi Prefectural Mikawa Aoitori Med & Rehabil Ctr, Dept Orthoped Surg, Okazaki, Japan
[5] Nagoya City Univ, Dept Pediat & Neonatol, Grad Sch Med Sci, Nagoya, Japan
[6] Osaka Univ, Dept Pediat, Grad Sch Med, Osaka, Japan
[7] Nagoya Univ, Dept Dev Disabil Med, Grad Sch Med, Nagoya, Japan
[8] Aichi Prefectural Mikawa Aoitori Med & Rehabil Ctr, Dept Pediat, 9-3 Koyaba, Koryuji Cho, Okazaki, Aichi, Japan
关键词
Ataxic-spastic gait; Gait analysis; Glucose transporter 1 deficiency syndrome; Modified Atkins diet; DEVIATION INDEX; RELIABILITY; DISORDERS;
D O I
10.1016/j.pediatrneurol.2022.04.012
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Of the patients with glucose transporter 1 deficiency syndrome (GLUT1-DS), 90% have a pathologic gait. Ataxic-spastic and ataxic gaits are seen in 35% of patients each. A ketogenic diet and modified Atkins diet (MAD) are effective therapy in GLUT1-DS in terms of both the seizures and movement disorder. A three-dimensional gait analysis (3DGA) system can be used to evaluate gait quantitatively using spatiotemporal data and gait kinematics. We performed 3DGA in three ambulatory patients with GLUT1-DS to evaluate the characteristics of their gait pathology, and we compared the gait variables before and after enhancing the MAD in one patient. Methods: After examination by pediatric neurologists and pediatric orthopedic surgeons, 3DGA was performed. We assessed walking speed, step length, step width, gait variability, Gait Deviation Index (GDI), Gait Profile Score (GPS), and Gait Variable Score (GVS). Results: All three patients had a low GDI and high GPS, comprehensive indices of gait pathology. The unstable gait pattern featured a wide step width in one patient and high gait variability in two patients. In the sagittal plane, the patients had increased GVSs in the knee and ankle joints due to excessive knee flexion or extension and excessive ankle plantarflexion. In the horizontal plane, the patients had increased GVSs in the pelvis, hips, and foot due to excessive rotation during walking. After enhancing the MAD, GDI, GPS, and GVSs improved. Conclusions: 3DGA has potential for quantifying the characteristics of gait pathology and its improvement with dietary therapy in patients with GLUT1-DS.
引用
收藏
页码:23 / 26
页数:4
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