Information and Computer Technologies have produced new generation interaction methods and services to support human activities, offering evolutionary learning procedures. 3D Virtual Worlds are sophisticated platforms supporting a set of human activities, enriching the way we learn, work and socialize. They are platforms that can support a constructivist learning approach of medical students, based on methods at the edge of technology inducing a team spirit and enhanced collaboration experience. In our work, we introduce the concept of e-learning through virtual worlds in medical and healthcare education, providing a literature review on the field. Furthermore, we discuss the advantages and disadvantages of virtual worlds in healthcare, we provide a comparison of the most popular platforms, while some open research issues are being considered in the conclusion.