Brucella spp. Virulence Factors and Immunity

被引：119
作者：
Byndloss, Mariana X. [1 ]
Tsolis, Renee M. [1 ]
机构：
[1] Univ Calif Davis, Sch Med, Dept Med Microbiol & Immunol, Davis, CA 95616 USA
来源：
ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 4 | 2016年 / 4卷
关键词：
brucellosis; immune response; reproduction; chronic disease; IV SECRETION SYSTEM; DENDRITIC CELL MATURATION; OVIS INFECTION; PPAR-GAMMA; CYTOKINE PRODUCTION; GENE POLYMORPHISMS; ABORTUS INFECTION; INTERFERON-GAMMA; IFN-GAMMA; TNF-ALPHA;
D O I：
10.1146/annurev-animal-021815-111326
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Brucellosis, caused by bacteria of the genus Brucella, is an important zoonotic infection that causes reproductive disease in domestic animals and chronic debilitating disease in humans. An intriguing aspect of Brucella infection is the ability of these bacteria to evade the host immune response, leading to pathogen persistence. Conversely, in the reproductive tract of infected animals, this stealthy pathogen is able to cause an acute severe inflammatory response. In this review, we discuss the different mechanisms used by Brucella to cause disease, with emphasis on its virulence factors and the dichotomy between chronic persistence and reproductive disease.
引用
收藏
页码：111 / 127
页数：17
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