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CHU Grenoble, Clin Univ Hepatogastroenterol, Inst Albert Bonniot, UJF IAPC,INSERM,U823, F-38043 Grenoble 9, France CHU Grenoble, Clin Univ Hepatogastroenterol, Inst Albert Bonniot, UJF IAPC,INSERM,U823, F-38043 Grenoble 9, France