Trends in antibiotic resistance among diarrheal pathogens isolated in Thailand over 15 years

被引：247

作者：

Hoge, CW

Gambel, JM

Srijan, A

Pitarangsi, C

Echeverria, P

机构：

[1] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Prevent Med, Washington, DC 20307 USA

[2] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Washington, DC 20307 USA

[3] Armed Forces Res Inst Med Sci, Dept Bacteriol Immunol & Mol Genet, Bangkok 10400, Thailand

来源：

CLINICAL INFECTIOUS DISEASES | 1998年 / 26卷 / 02期

关键词：

D O I：

10.1086/516303

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibiotic resistance trends were examined for Shigella species, nontyphoidal Salmonella species, enterotoxigenic Escherichia coli (ETEC), and Campylobacter species isolates from indigenous persons and travelers in Thailand for up to 15 years, Resistance to trimethoprim-sulfamethoxazole was found in >90% of Shigella and 40% of ETEC and nontyphoidal Salmonella isolates. Resistance to nalidixic acid was found in 97%-100% of Shigella dysenteriae 1 strains isolated between 1992 and 1995. Ciprofloxacin resistance was detected in 1% of ETEC isolates in 1994 and 1995 and in one of 349 nontyphoidal Salmonella isolates in 1995. Ciprofloxacin resistance among Campylobacter species increased from zero before 1991 to 84% in 1995 (P<.0001). Azithromycin resistance was found in 7%-15% of Campylobacter isolates in 1994 and 1995, as well as 15% of ETEC and 3% of Salmonella isolates in 1995. Enteric pathogens in Thailand have developed resistance to virtually all antibiotics routinely used in the treatment of diarrhea, as well as the newer fluoroquinolone and macrolide classes of drugs.

引用

页码：341 / 345

页数：5