HIV and Stem Cell Transplantation

被引：4
作者：
Echenique, Ignacio A. [1 ]
Nelson, George E. [3 ]
Stosor, Valentina [1 ,2 ]
Durand, Christine M. [3 ,4 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Infect Dis, Chicago, IL 60611 USA
[2] Northwestern Univ, Feinberg Sch Med, Dept Surg, Div Organ Transplantat, Chicago, IL 60611 USA
[3] Johns Hopkins Sch Med, Dept Med, Div Infect Dis, Baltimore, MD 21287 USA
[4] Johns Hopkins Sch Med, Div Infect Dis, Baltimore, MD 21204 USA
来源：
CURRENT INFECTIOUS DISEASE REPORTS | 2014年 / 16卷 / 09期
关键词：
AIDS; Allogeneic stem cell transplantation; Antiretroviral therapy; Autologous stem cell transplantation; Bone marrow transplantation; GVHD; HIV; HIV cure; HIV eradication; HIV reservoir; Hodgkin lymphoma; Non-Hodgkin lymphoma; Stem cell transplantation; HUMAN-IMMUNODEFICIENCY-VIRUS; BONE-MARROW-TRANSPLANTATION; ACTIVE ANTIRETROVIRAL THERAPY; NON-HODGKIN-LYMPHOMA; HIGH-DOSE THERAPY; BLOOD PROGENITOR CELLS; UNITED-STATES; CORD BLOOD; IMMUNE RECONSTITUTION; UNRELATED DONORS;
D O I：
10.1007/s11908-014-0424-y
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
In human immunodeficiency virus (HIV)-infected persons, the incidence of hematologic malignancies, including leukemia and lymphoma, is increased despite the use of successful antiretroviral therapy. Hematopoietic stem cell transplantation (SCT) is emerging as a safe and effective therapy for HIV-infected persons with hematologic malignancies. Management of these patients is complicated by drug-drug interactions involving antiretroviral therapy (ART) that may impact conditioning agent efficacy and metabolism of immunosuppressive medications and potentiate drug toxicities. As such, optimal strategies for ART remain controversial. We discuss recent advances, controversies, and future directions related to SCT in HIV-infected persons, including the investigation of allogeneic SCT as a strategy for HIV cure.
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页码：1 / 10
页数：10
相关论文
共 110 条
  • [1] ABOULAFIA DM, 1991, AIDS, V5, P344
  • [2] HIV Viremia and Incidence of Non-Hodgkin Lymphoma in Patients Successfully Treated With Antiretroviral Therapy
    Achenbach, Chad J.
    Buchanan, Ashley L.
    Cole, Stephen R.
    Hou, Lifang
    Mugavero, Michael J.
    Crane, Heidi M.
    Moore, Richard D.
    Haubrich, Richard H.
    Gopal, Satish
    Eron, Joseph J.
    Hunt, Peter W.
    Rodriguez, Benigno
    Mayer, Kenneth
    Saag, Michael S.
    Kitahata, Mari M.
    [J]. CLINICAL INFECTIOUS DISEASES, 2014, 58 (11) : 1599 - 1606
  • [3] Mortality after cancer diagnosis in HIV-infected individuals treated with antiretroviral therapy
    Achenbach, Chad J.
    Cole, Stephen R.
    Kitahata, Mari M.
    Casper, Corey
    Willig, James H.
    Mugavero, Michael J.
    Saag, Michael S.
    [J]. AIDS, 2011, 25 (05) : 691 - 700
  • [4] CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1
    Alkhatib, G
    Combadiere, C
    Broder, CC
    Feng, Y
    Kennedy, PE
    Murphy, PM
    Berger, EA
    [J]. SCIENCE, 1996, 272 (5270) : 1955 - 1958
  • [5] Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: Myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients
    Amado, RG
    Mitsuyasu, RT
    Rosenblatt, JD
    Ngok, FK
    Bakker, A
    Cole, S
    Chorn, N
    Lin, LS
    Bristol, G
    Boyd, MP
    Macpherson, JL
    Fanning, GC
    Todd, AV
    Ely, JA
    Zack, JA
    Symonds, GP
    [J]. HUMAN GENE THERAPY, 2004, 15 (03) : 251 - 262
  • [6] ANGELUCCI E, 1990, HAEMATOLOGICA, V75, P285
  • [7] Better response to chemotherapy and prolonged survival in AIDS-related lymphomas responding to highly active antiretroviral therapy
    Antinori, A
    Cingolani, A
    Alba, L
    Ammassari, A
    Serraino, D
    Ciancio, BC
    Palmieri, F
    De Luca, A
    Larocca, LM
    Ruco, L
    Ippolito, G
    Cauda, R
    [J]. AIDS, 2001, 15 (12) : 1483 - 1491
  • [8] Appleby P, 2000, JNCI-J NATL CANCER I, V92, P1823, DOI 10.1093/jnci/92.22.1823
  • [9] Failure of bone marrow transolantation to eradicate HIV reservoir desoite efficient HAART
    Avettand-Fenoel, Veronique
    Mahlaoui, Nizar
    Chaix, Marie-Laure
    Milliancourt, Catherine
    Burgard, Marianne
    Cavazzana-Calvo, Marina
    Rouzioux, Christine
    Blanche, Stephane
    [J]. AIDS, 2007, 21 (06) : 776 - 777
  • [10] Autologous Stem-Cell Transplantation in Patients With HIV-Related Lymphoma
    Balsalobre, Pascual
    Diez-Martin, Jose L.
    Re, Alessandro
    Michieli, Mariagrazia
    Ribera, Jose M.
    Canals, Carmen
    Rosselet, Anne
    Conde, Eulogio
    Varela, Rosario
    Cwynarski, Kate
    Gabriel, Ian
    Genet, Philippe
    Guillerm, Gaelle
    Allione, Bernardino
    Ferrant, Augustin
    Biron, Pierre
    Espigado, Ildefonso
    Serrano, David
    Sureda, Anna
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (13) : 2192 - 2198
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