Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid-induced liver injury

被引：13
作者：
Mohammed, Marwa Abdeltawab [1 ]
Gharib, Doaa Mostafa [2 ]
Reyad, Hoda Ramadan [3 ]
Mohamed, Alaa Aboud [3 ]
Elroby, Fadwa A. [4 ]
Mahmoud, Hoda Sayed [4 ]
机构：
[1] Beni Suef Univ, Fac Med Beni, Dept Physiol, Bani Suwayf, Egypt
[2] Cairo Univ, Fac Med, Dept Biochem, Cairo, Egypt
[3] Beni Suef Univ, Fac Med, Dept Biochem, Bani Suwayf, Egypt
[4] Beni Suef Univ, Fac Med, Dept Forens Med & Toxicol, Bani Suwayf, Egypt
来源：
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2021年 / 99卷 / 05期
关键词：
alpha-lipoic acid; valproic acid; nuclear factor erythroid 2-related factor 2; sirtuin; 1; tumor necrosis factor alpha; superoxide dismutase; glutathione; NECROSIS-FACTOR-ALPHA; INDUCED HEPATOTOXICITY; OXIDATIVE STRESS; HISTONE DEACETYLASE; SODIUM VALPROATE; NRF2; ACTIVATION; SIRT1; INDUCTION; APOPTOSIS; TOXICITY;
D O I：
10.1139/cjpp-2019-0456
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Valproic acid (VPA) is one of the most used antiepileptic drugs despite of its many adverse effects such as anemia, leucopenia, thrombocytopenia, and liver toxicity. The hepatoprotective effect of alpha-lipoic acid (ALA) was confirmed. The aim of this study was to detect the protective effect of ALA against the adverse effects of VPA. To study this, 30 white albino Wistar male rats were divided into four groups. Group I was the control group; Group II included rats that received ALA (100 mg.kg(-1).day(-1) orally for 14 days; Group III and Group N included rats that received VPA (500 mg.kg(-1).day(-1)) for 15 days intraperitoneally, but Group IV rats received ALA (100 mg.kg(-1).day(-1)) orally for 14 days prior to VPA. Blood samples were collected and livers were excised from rats for colorimetric analysis and quantitative real-time PCR. The rats that received VPA showed leucopenia, thrombocytopenia, a significant decrease of superoxide dismutase, glutathione, nuclear factor erythroid 2-related factor 2, and sirtuin 1, besides a significant increase of malondialdehyde and tumor necrosis factor a. Prior treatment with ALA prevented all these results; ALA protected against VPA-induced liver damage and hematological disturbance via antioxidant and anti-inflammatory properties.
引用
收藏
页码：499 / 505
页数：7
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