Cystathionine β-synthase 844Ins68 polymorphism is not associated with the levels of homocysteine and cysteine in an Indian population

被引：11
作者：
Kumar, Jitender [1 ]
Garg, Gaurav [1 ]
Karthikeyan, Ganesan [2 ]
Sengupta, Shantanu [1 ]
机构：
[1] Inst Genom & Integrat Biol, Council Sci & Ind Res, Delhi 110007, India
[2] All India Inst Med Sci, New Delhi, India
来源：
BIOMARKERS | 2010年 / 15卷 / 03期
关键词：
CBS; 844Ins68; CHDH A119C; homocysteine; Indian population; MTHFR C677T; PLASMA HOMOCYSTEINE; HIGH-FREQUENCY; VARIANT; COMMON; MTHFR; GENE; HOMOCYSTINURIA; DEFICIENCY; METABOLISM; MUTATION;
D O I：
10.3109/13547501003658106
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Cystathionine beta-synthase (CBS) is a key enzyme that plays a critical role in homocysteine metabolism and intracellular redox balance. We have analysed the association of the CBS 844Ins68 polymorphism alone and in combination with methylenetetrahydrofolate reductase (MTHFR C677T) and choline dehydrogenase (CHDH A119C) polymorphisms (the two polymorphisms recently shown to be associated with levels of homocysteine) with homocysteine, cysteine, folate and vitamin B-12 in 817 individuals (397 patients with coronary artery disease and 420 controls). The CBS 844Ins68 polymorphism alone or in combination with MTHFR C677T and CHDH A119C polymorphisms was not significantly associated with any of the biochemical variables studied.</.
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收藏
页码：283 / 287
页数：5
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