Role of zinc in blockade of excitotoxic action of quinolinic acid by picolinic acid

被引：20
作者：
Jhamandas, KH [1 ]
Boegman, RJ [1 ]
Beninger, RJ [1 ]
Flesher, S [1 ]
机构：
[1] Queens Univ, Dept Pharmacol & Toxicol, Kingston, ON K7L 3N6, Canada
来源：
AMINO ACIDS | 1998年 / 14卷 / 1-3期
关键词：
picolinic acid; quinolinic acid; zinc; excitotoxicity;
D O I：
10.1007/BF01345272
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study examined whether picolinic acid (PIC) inhibits quinolinic acid (QUIN)-induced excitotoxicity through zinc chelation. Injection of QUIN into the nucleus basalis magnocellularis significantly depleted cortical choline acetyltransferase activity 7 days post injection and PIC inhibited this response. Zinc augmented the QUIN- but not NMDA-induced response. When PIC was co-administered with zinc, PIC failed to attenuate the QUIN-induced response. The inhibition of QUIN-induced cholinergic toxicity by PIC may involve chelation of zinc.
引用
收藏
页码：257 / 261
页数：5
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