Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes

被引：27

作者：

Grcevic, Danka ^{[1
]}

Kusec, Rajko ^{[2
]}

Kovacic, Natasa ^{[3
]}

Lukic, Anita ^{[1
]}

Lukic, Ivan Kresimir ^{[3
,4
]}

Ivcevic, Sanja ^{[1
]}

Nemet, Damir ^{[5
]}

Seiwerth, Ranka Serventi ^{[5
]}

Ostojic, Slobodanka Kolonic ^{[6
]}

Croucher, Peter I. ^{[7
]}

Marusic, Ana ^{[3
,8
]}

机构：

[1] Univ Zagreb, Sch Med, Dept Physiol & Immunol, Zagreb 10000, Croatia

[2] Univ Zagreb, Sch Med, Dubrava Univ Hosp, Dept Hematol, Zagreb 10000, Croatia

[3] Univ Zagreb, Sch Med, Dept Anat, Zagreb 10000, Croatia

[4] Biosistemi DOO, Zagreb, Croatia

[5] Univ Zagreb, Sch Med, Ctr Hosp, Dept Hematol, Zagreb 10000, Croatia

[6] Univ Zagreb, Sch Med, Merkur Univ Hosp, Dept Hematol, Zagreb 10000, Croatia

[7] Univ Sheffield, Sch Med, Acad Unit Bone Biol, Sect Musculoskeletal Sci, Sheffield, S Yorkshire, England

[8] Univ Split, Sch Med, Dept Anat, Split, Croatia

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 06期

关键词：

Multiple myeloma; Bone morphogenetic proteins; Bone-marrow; Cell lines; ID genes; Cell survival; SIGNALING PATHWAYS; APOPTOSIS; GROWTH; SURVIVAL; INVASION; DIFFERENTIATION; PROLIFERATION; PATHOGENESIS; DYSFUNCTION; TARGET;

D O I：

10.1016/j.leukres.2009.10.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We assessed the expression pattern and clinical relevance of BMPs and related molecules in multiple myeloma (MM). MM bone-marrow samples (n = 32) had increased BMP4, BMP6, ACVR1 and ACVR2A, and decreased NOG expression compared with controls (n = 15), with BMP6 having the highest sensitivity/specificity. Within MM bone-marrow, the source of BMPs was mainly CD138(+) plasma-cell population, and BMP6 and ACVR1 expression correlated with plasma-cell percentage. Using myeloma cell lines NCI H929 and Thiel we showed that BMPs induced ID1, ID2 and IL6, and suppressed CDKN1A and BAX gene expression, and BAX protein expression. Finally, BMPs partially protected myeloma cells from bortezomib- and TRAIL-induced apoptosis. We concluded that BMPs may be involved in MM pathophysiology and serve as myeloma cell biomarkers. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：742 / 751

页数：10

共 50 条

[1] Treatment of multiple myeloma [J].