Association between Lipid Profiles and the Incidence of Hepatocellular Carcinoma: A Nationwide Population-Based Study

被引：35

作者：

Cho, Yuri ^{[1
,2
]}

Cho, Eun Ju ^{[3
,4
]}

Yoo, Jeong-Ju ^{[5
]}

Chang, Young ^{[6
]}

Chung, Goh Eun ^{[7
]}

Jeong, Su-Min ^{[8
,9
]}

Park, Sang-Hyun ^{[10
]}

Han, Kyungdo ^{[10
]}

Shin, Dong Wook ^{[11
,12
]}

Yu, Su Jong ^{[3
,4
]}

机构：

[1] Natl Canc Ctr, Ctr Liver & Pancreatobiliary Canc, Goyang 10408, South Korea

[2] CHA Univ, Dept Internal Med, CHA Gangnam Med Ctr, Sch Med, Seoul 06135, South Korea

[3] Seoul Natl Univ, Dept Internal Med, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea

[4] Seoul Natl Univ, Liver Res Inst, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea

[5] Soonchunhyang Univ, Dept Gastroenterol & Hepatol, Bucheon Hosp, Bucheon 14584, South Korea

[6] Soonchunhyang Univ, Dept Gastroenterol & Hepatol, Seoul Hosp, Seoul 04401, South Korea

[7] Seoul Natl Univ Hosp, Dept Internal Med, Inst Healthcare Res, Gangnam Healthcare Ctr, Seoul 06236, South Korea

[8] Seoul Natl Univ, Dept Family Med, Seoul Metropolitan Govt, Boramae Med Ctr, Seoul 07061, South Korea

[9] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[10] Soongsil Univ, Dept Biostat, Coll Med, Seoul 06978, South Korea

[11] Samsung Comprehens Canc Ctr, Dept Family Med, Samsung Med Ctr, Support Care Ctr, Seoul 06351, South Korea

[12] Sungkyunkwan Univ, Dept Digital Hlth, SAIHST, 81 Irwon Ro, Seoul 06351, South Korea

来源：

CANCERS | 2021年 / 13卷 / 07期

关键词：

cholesterol; low-density lipoprotein; hepatocellular carcinoma; lipid metabolism;

D O I：

10.3390/cancers13071599

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary: Cholesterol plays an important role in cell structure and cell proliferation. Altered lipid metabolism have been implicated in the development of hepatocellular carcinoma (HCC). This study investigated the relationships between lipid profiles and HCC development using large-scale, nationally representative data from the Korean National Health Insurance Service. During a median of 7.3 years follow-up, 26,891 incident HCCs were identified. The incidence of HCC gradually decreased according to the increase of total-cholesterol and LDL-cholesterol. This inverse association was consistent across subgroups stratified by the presence of liver cirrhosis or viral hepatitis. This large nationwide population-based study suggests that low lipid profile is an independent risk factor and preclinical marker for HCC. Background and Aims: Altered lipid metabolism has been implicated in the development of hepatocellular carcinoma (HCC). This study investigated the relationships between lipid profiles and HCC development. Methods: Data were obtained from the Korean National Health Insurance Service from 2009 to 2017. Cox regression analysis was used to examine the hazard ratios of HCC in 8,528,790 individuals who had undergone health check-ups in 2009. Results: During a median of 7.3 years follow-up, 26,891 incidents of HCCs were identified. The incidence of HCC (per 100,000 person-years) gradually decreased according to the increase in total-cholesterol and LDL-cholesterol; the incidence of HCC was 69.2, 44.0, 33.9, and 25.8 in quartile-1 (Q1), Q2, Q3, and Q4 population of total-cholesterol, and 63.6, 44.5, 37.2, and 28.3 in Q1, Q2, Q3, and Q4 population of LDL-cholesterol, respectively. Compared to Q1 of total-cholesterol, subjects in higher total-cholesterol levels were associated with a lower incidence of HCC (multiple covariates-adjusted hazard ratio (aHR): Q2 0.61; Q3 0.46; Q4 0.36). These associations were consistently observed in stratified subgroup analysis by the presence of liver cirrhosis or viral hepatitis. Conclusions: Low serum lipid levels were significantly associated with the increased risk of developing HCC. A low lipid profile might be an independent risk factor and preclinical marker for HCC.

引用

页数：10

共 30 条

[1]

Ahaneku J. E., 1992, JPMA (Journal of the Pakistan Medical Association), V42, P260

[2] SERUM-LIPIDS IN HEPATOMA [J].