Effects of aging on the human motor cortical plasticity studied by paired associative stimulation

被引：126

作者：

Fathi, Dina ^{[1
]}

Ueki, Yoshino ^{[1
]}

Mima, Tatsuya ^{[1
]}

Koganemaru, Satoko ^{[1
]}

Nagamine, Takashi ^{[1
]}

Tawfik, Amal

Fukuyama, Hidenao ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Human Brain Res Ctr, Sakyo Ku, Kyoto 6068507, Japan

来源：

CLINICAL NEUROPHYSIOLOGY | 2010年 / 121卷 / 01期

基金：

日本学术振兴会;

关键词：

Plasticity; Aging; Dopamine; Transcranial magnetic stimulation; TRANSCRANIAL MAGNETIC STIMULATION; SOMATOSENSORY-EVOKED POTENTIALS; AGE-DEPENDENT CHANGES; CORTEX EXCITABILITY; NEUROTROPHIC FACTOR; PARKINSONS-DISEASE; CENTRAL CONDUCTION; HUMAN-BRAIN; RESPONSES; NEURONS;

D O I：

10.1016/j.clinph.2009.07.048

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To test whether the normal aging itself may change the cortical plasticity in human. Methods: Motor-evoked potentials (MEPs) were measured from 48 right-handed healthy volunteers (age 21-79) before and after the paired associative stimulation (PAS), comprising a single electric stimulus to the right median nerve at wrist and subsequent transcranial magnetic stimulation (TMS) of the left primary motor cortex. Results: The magnitude of MEP increased by PAS in the young and middle but not in the elderly and its change was negatively correlated with the age. Conclusions: These results suggest that the human M1 shows age-dependent reduction of cortical plasticity. Significance: The reduction of the M1 plasticity maybe caused by the attenuated responsiveness of intracortical circuits in the M1 and/or disrupted sensorimotor integration within basal ganglia-thalamocortical loop. (C) 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：90 / 93

页数：4

共 32 条

[1] Motor but not sensory representation in motor cortex depends on postsynaptic activity during development and in maturity [J].