Execution mechanisms of programmed cell death by caspase (ICE/CED3) family proteases

被引：0
|
作者：
Miura, M [1 ]
Hisahara, S [1 ]
Araki, T [1 ]
Okano, H [1 ]
机构：
[1] Osaka Univ, Sch Med, Dept Neuroanat, Biomed Res Ctr, Osaka 565, Japan
来源：
HEART AND VESSELS | 1997年
关键词：
apoptosis; programmed cell death; ICE; CED3; caspase;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Molecular genetic study of Caenorhabditis elegans revealed the cell death-executing gene ced-3 Structural and functional similarities between CED-3 and mammalian ICE family (caspase) gene products provide the evidence that mammalian caspases are common mediators in executing programmed cell death. These findings suggest that the execution mechanisms of cell death by caspase family protease may be evolutionarily conserved from worms to mammals. This report summarizes the unique properties of caspases in apoptosis.
引用
收藏
页码：66 / 70
页数：5
相关论文
共 50 条
  • [1] Role of Ced3/ICE-family proteases in staurosporine-induced programmed cell death
    Jacobson, MD
    Weil, M
    Raff, MC
    JOURNAL OF CELL BIOLOGY, 1996, 133 (05): : 1041 - 1051
  • [2] Regulation of programmed cell death by protease ICE/CED-3 family
    Miura, M
    JOURNAL OF BRAIN RESEARCH-JOURNAL FUR HIRNFORSCHUNG, 1996, 37 (04): : 579 - 580
  • [3] Proapoptotic ICE/ced3 cysteine proteases: future prospects for pharmacological inhibition
    Mignon, A
    Rouquet, N
    Joulin, V
    M S-MEDECINE SCIENCES, 1998, 14 (01): : 9 - 17
  • [4] Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases
    Kamada, S
    Funahashi, Y
    Tsujimoto, Y
    CELL DEATH AND DIFFERENTIATION, 1997, 4 (06): : 473 - 478
  • [5] Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases
    Shinji Kamada
    Yoshimitsu Funahashi
    Yoshihide Tsujimoto
    Cell Death & Differentiation, 1997, 4 : 473 - 478
  • [6] The ICE/Ced-3-family proteases as the apoptotic executioner
    Green, DR
    Martin, SJ
    CELL DEATH AND DIFFERENTIATION, 1996, 3 (03): : 339 - 340
  • [7] Targeted expression of ced-3 and Ice induces programmed cell death in Drosophila
    Shigenaga, A
    Funahashi, Y
    Kimura, K
    Kobayakawa, Y
    Kamada, S
    Tsujimoto, Y
    Tanimura, T
    CELL DEATH AND DIFFERENTIATION, 1997, 4 (05): : 371 - 377
  • [8] Targeted expression of ced-3 and Ice induces programmed cell death in Drosophila
    Ayako Shigenaga
    Yoshimistu Funahashi
    Ken-ichi Kimura
    Yoshitaka Kobayakawa
    Shinji Kamada
    Yoshihide Tsujimoto
    Teiichi Tanimura
    Cell Death & Differentiation, 1997, 4 : 371 - 377
  • [9] Brefeldin A-induced programmed cell death is inhibited by CED-3/ICE family protease inhibitors.
    Guo, H
    Tittle, TV
    Maziarz, RT
    BLOOD, 1996, 88 (10) : 641 - 641
  • [10] ROLE OF MULTIPLE CELLULAR PROTEASES IN THE EXECUTION OF PROGRAMMED CELL-DEATH
    KUMAR, S
    HARVEY, NL
    FEBS LETTERS, 1995, 375 (03) : 169 - 173
12345