Synthesis, Crystal Structure and Anti-Leukemic Activity of 1,3-Dihydro-1-{1-[4-(4-phenylpyrrolo [1,2-a]quinoxalin-3-yl)benzyl]piperidin-4-yl}-2H-benzimidazol-2-one

被引：7
作者：
Guillon, Jean [1 ]
Savrimoutou, Solene [1 ]
Albenque-Rubio, Sandra [1 ]
Pinaud, Noel [2 ]
Moreau, Stephane [1 ]
Desplat, Vanessa [3 ]
机构：
[1] Univ Bordeaux, Fac Pharm, ARNA, INSERM U1212,UMR CNRS 5320, F-33000 Bordeaux, France
[2] Univ Bordeaux, ISM, CNRS UMR 5255, F-33405 Talence, France
[3] Univ Bordeaux, Fac Pharm, INSERM U1312, BRIC, 146 Rue Leo Saignat, F-33076 Bordeaux, France
来源：
MOLBANK | 2022年 / 2022卷 / 01期
关键词：
pyrrolo[1,2-a]quinoxaline derivative; leukemia; antiproliferative activity; ANTIMALARIAL ACTIVITY; BIOLOGICAL EVALUATION; POTENTIAL INHIBITORS; DERIVATIVES; DESIGN; ETHYL;
D O I：
10.3390/M1333
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1,3-Dihydro-1-{1[4-(4-phenylpyrrolo[1,2-a]quinoxalin-3-yl)benzyl]piperidin-4-yl}-2H-benzi midazol-2-one has been synthesized through a multi-step pathway starting from commercially available 2-nitroaniline. A structure characterization of this new substituted pyrrolo[1,2-a]quinoxaline compound was achieved by using FT-IR, H-1-NMR, C-13-NMR, X-Ray and HRMS spectral analysis. This new pyrroloquinoxaline derivative shows an interesting cytotoxic potential against several human leukemia cell lines (HL60, K562 and U937 cells).
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页数：7
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