Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor

被引：53

作者：

Harada, Shinji ^{[1
]}

Takita, Ryo ^{[1
]}

Ohshima, Takashi ^{[1
]}

Matsunaga, Shigeki ^{[1
]}

Shibasaki, Masakatsu ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 09期

关键词：

D O I：

10.1039/b614958h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Indium(III)-catalyzed asymmetric alkynylation of aryl, heteroaryl, alkyl and alkenyl aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor was realized, and products were obtained in moderate to good yields (up to 97%) and high enantioselectivities (up to 99% ee) using 2-10 mol% of catalyst.

引用

页码：948 / 950

页数：3

共 36 条

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