Effects of paeonol on proliferation and collagen synthesis of rat cardiac fibroblasts induced by aldosterone

被引：1

作者：

Xu, Qian ^{[1
]}

Wang, Li-Na ^{[1
]}

Zhao, Jing-Yi ^{[1
]}

Xiao, Yan-Hong ^{[1
]}

Du, Chao ^{[1
]}

机构：

[1] Chengde Med Univ, Dept Biochem, Chengde 067000, Hebei, Peoples R China

来源：

BANGLADESH JOURNAL OF PHARMACOLOGY | 2021年 / 16卷 / 02期

关键词：

FIBROSIS; CELLS; SPIRONOLACTONE; EXPRESSION; INFARCTION; PATHWAYS; MUSCLE;

D O I：

10.3329/bjp.v16i2.51605

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to explore the possible molecular mechanisms of paeonol in preventing ventricular remodeling. The cell viability of neonatal rat cardiac fibroblasts was detected by the method of MTT. RT-PCR and Western blot were used to measure the expression of TGF-beta 1, type I collagen and type III collagen. After treating the cardiac fibroblasts with paeonol, the cell viability decreased (p<0.01), and the expression of TGF-beta 1, type I collagen and types III collagen was significantly reduced (p<0.01). Thus, paeonol can inhibit the proliferation of fibroblast cells induced by aldosterone. The molecular mechanism is related to the down-regulation of TGF-beta(1) and type I and III collagen gene expression.

引用

页码：42 / 48

页数：7

共 37 条

[1] TRANSFORMING GROWTH FACTOR-BETA(1) GENE ACTIVATION AND GROWTH OF SMOOTH-MUSCLE FROM HYPERTENSIVE RATS [J].

AGROTIS, A ;

SALTIS, J ;

BOBIK, A .

HYPERTENSION, 1994, 23 (05) :593-599

[2] The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy [J].

Asbun, J ;

Villarreal, FJ .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (04) :693-700

[3] MTT assay to evaluate the cytotoxic potential of a drug [J].

Bahuguna, Ashutosh ;

Khan, Imran ;

Bajpai, Vivek K. ;

Kang, Sun Chul .

BANGLADESH JOURNAL OF PHARMACOLOGY, 2017, 12 (02) :115-118

[4] Role of proteoglycans in the regulation of the skeletal muscle fibrotic response [J].

Brandan, Enrique ;

Gutierrez, Jaime .

FEBS JOURNAL, 2013, 280 (17) :4109-4117

[5] COLLAGEN-METABOLISM IN CULTURED ADULT-RAT CARDIAC FIBROBLASTS - RESPONSE TO ANGIOTENSIN-II AND ALDOSTERONE [J].

BRILLA, CG ;

ZHOU, GP ;

MATSUBARA, L ;

WEBER, KT .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1994, 26 (07) :809-820

[6]

[曹政 Cao Zheng], 2003, [中国动脉硬化杂志, Chinese Journal of Arteriosclerosis], V11, P135

[7] Omentin-1 is associated with atrial fibrillation in patients with cardiac valve disease [J].

Chen, Yubin ;

Liu, Fen ;

Han, Fei ;

Lv, Lizhi ;

Tang, Can-e ;

Xie, Zhongshang ;

Luo, Fanyan .

BMC CARDIOVASCULAR DISORDERS, 2020, 20 (01)

[8]

Dartsch T, 2013, INT J CARDIOL, V164, P170, DOI 10.1016/j.ijcard.2011.06.100

[9] Smad-dependent and Smad-independent pathways in TGF-β family signalling [J].

Derynck, R ;

Zhang, YE .

NATURE, 2003, 425 (6958) :577-584

[10]

Fan J, 2009, CHONGQING CHINESE HE, V6, P24

← 1 2 3 4 →