Tailored drug-release from multi-functional polymer-peptide hybrid vesicles

被引：27

作者：

Bacinello, Daniel ^{[1
,2
,3
]}

Garanger, Elisabeth ^{[1
,2
,4
]}

Taton, Daniel ^{[1
,2
]}

Tam, Kam Chui ^{[3
]}

Lecommandoux, Sebastien ^{[1
,2
]}

机构：

[1] Univ Bordeaux, LCPO, UMR 5629, F-33600 Pessac, France

[2] CNRS, LCPO, UMR 5629, F-33600 Pessac, France

[3] Univ Waterloo, Waterloo Inst Nanotechnol, Dept Chem Engn, Waterloo, ON N2L 3G1, Canada

[4] IECB, F-33600 Pessac, France

来源：

EUROPEAN POLYMER JOURNAL | 2015年 / 62卷

关键词：

Matrix metalloproteinase; Drug delivery systems; Poly(trimethylene carbonate); Thiol-ene; Cancer targeting; Polymersome; BLOCK-COPOLYMERS; MICELLES; NANOCARRIERS; DELIVERY;

D O I：

10.1016/j.eurpolymj.2014.09.001

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The synthetic semi-crystalline polymer poly(trimethylene carbonate) PTMC50 was linked to the synthetic poly(amino acid) poly(glutamic acid) (PGA(15)) using the peptide PVGLIG, known to be selectively cleaved by the tumor-associated enzyme matrix metalloproteinase 2 (MMP-2), by a combination of thiol-ene coupling and ring-opening polymerization. Stable, monodisperse, sub-micron sized polymersomes were subsequently obtained by self-assembly and characterized by dynamic and static light scattering (DLS and SLS) and transmission electron microscopy (TEM). These vesicles showed selective degradation in the presence of MMP-2 as probed by DLS. The model drug imipramine hydrochloride was loaded at 35% encapsulation efficiency by co-precipitation and displayed controlled drug-release behavior. Drug release rates showed several fold increases when exposed to pH, temperature and most significantly, to the tumor-associated enzyme MMP-2. Such structures, bearing precise location of the cleavable peptide sequence, may hold promise as future specific and controlled drug-delivery systems. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：363 / 373

页数：11

共 37 条

[1] pH and Temperature Responsive Polymeric Micelles and Polymersomes by Self-Assembly of Poly[2-(dimethylamino)ethyl methacrylate]-b-Poly(glutamic acid) Double Hydrophilic Block Copolymers [J].