The Role of Matrix Metalloproteinase 2 on the Survival of Patients with Non-Small Cell Lung Cancer: A Systematic Review with Meta-Analysis

被引：83
|
作者：
Qian, Qian [1 ]
Wang, Qian [1 ]
Zhan, Ping [2 ]
Peng, Ling [3 ]
Wei, Shu-Zhen [1 ]
Shi, Yi [1 ]
Song, Yong [1 ]
机构：
[1] Nanjing Univ, Dept Resp Med, Jinling Hosp, Sch Med, Nanjing 210002, Peoples R China
[2] Nanjing Chest Hosp, Dept Resp Med, Nanjing 210029, Peoples R China
[3] Jinling Hosp, Dept Med Oncol, Nanjing 210002, Peoples R China
来源：
CANCER INVESTIGATION | 2010年 / 28卷 / 06期
关键词：
Matrix Metalloproteinase 2; NSCLC; Meta-analysis; Prognosis; PROGNOSTIC-FACTOR; PUBLICATION BIAS; EXPRESSION; MMP-2; ADENOCARCINOMA; INHIBITORS; CARCINOMA; OVEREXPRESSION; PROGRESSION; TRIALS;
D O I：
10.3109/07357901003735634
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To evaluate the prognostic value of Matrix Metalloproteinase2 (MMP-2) expression in patients with non-small cell lung cancer (NSCLC), the electronic database PubMed, EMBASE were searched for relevant articles. The meta-analysis was finally based on 11 studies that included 1,439 patients, and combined HR was 1.66 (95% confidence intervals (Cl: 1.37-2.01). Its effect also appeared significant when the analysis was restricted to tumor cell expression and patients with adenocarcinoma (HR 2.08 (95% Cl: 1.24-3.48)). This study supported the fact that MMP-2 could be included in further prospective trials studying prognostic factors in NSCLC.
引用
收藏
页码：661 / 669
页数：9
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