The Role of Matrix Metalloproteinase 2 on the Survival of Patients with Non-Small Cell Lung Cancer: A Systematic Review with Meta-Analysis

被引：83
作者：
Qian, Qian [1 ]
Wang, Qian [1 ]
Zhan, Ping [2 ]
Peng, Ling [3 ]
Wei, Shu-Zhen [1 ]
Shi, Yi [1 ]
Song, Yong [1 ]
机构：
[1] Nanjing Univ, Dept Resp Med, Jinling Hosp, Sch Med, Nanjing 210002, Peoples R China
[2] Nanjing Chest Hosp, Dept Resp Med, Nanjing 210029, Peoples R China
[3] Jinling Hosp, Dept Med Oncol, Nanjing 210002, Peoples R China
来源：
CANCER INVESTIGATION | 2010年 / 28卷 / 06期
关键词：
Matrix Metalloproteinase 2; NSCLC; Meta-analysis; Prognosis; PROGNOSTIC-FACTOR; PUBLICATION BIAS; EXPRESSION; MMP-2; ADENOCARCINOMA; INHIBITORS; CARCINOMA; OVEREXPRESSION; PROGRESSION; TRIALS;
D O I：
10.3109/07357901003735634
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To evaluate the prognostic value of Matrix Metalloproteinase2 (MMP-2) expression in patients with non-small cell lung cancer (NSCLC), the electronic database PubMed, EMBASE were searched for relevant articles. The meta-analysis was finally based on 11 studies that included 1,439 patients, and combined HR was 1.66 (95% confidence intervals (Cl: 1.37-2.01). Its effect also appeared significant when the analysis was restricted to tumor cell expression and patients with adenocarcinoma (HR 2.08 (95% Cl: 1.24-3.48)). This study supported the fact that MMP-2 could be included in further prospective trials studying prognostic factors in NSCLC.
引用
收藏
页码：661 / 669
页数：9
相关论文
共 31 条
  • [1] PUBLICATION BIAS AND DISSEMINATION OF CLINICAL RESEARCH
    BEGG, CB
    BERLIN, JA
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (02) : 107 - 115
  • [2] OPERATING CHARACTERISTICS OF A BANK CORRELATION TEST FOR PUBLICATION BIAS
    BEGG, CB
    MAZUMDAR, M
    [J]. BIOMETRICS, 1994, 50 (04) : 1088 - 1101
  • [3] Association between cyclooxygenase-2 and matrix metalloproteinase-2 expression in non-small cell lung cancer
    Byun, Jae Ho
    Lee, Myung Ah
    Roh, Sang Young
    Shim, Byoung Yong
    Hong, Sook Hee
    Ko, Yoon Ho
    Ko, Su Jin
    Woo, In Sook
    Kang, Jin Hyoung
    Hong, Young Seon
    Lee, Kyung Shik
    Lee, Ah Won
    Park, Gyeong Sin
    Lee, Kyo Yeong
    [J]. JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2006, 36 (05) : 263 - 268
  • [4] A biological staging model for operable non-small cell lung cancer
    Cox, G
    Jones, JL
    Andi, A
    Waller, DA
    O'Byrne, KJ
    [J]. THORAX, 2001, 56 (07) : 561 - 566
  • [5] METAANALYSIS IN CLINICAL-TRIALS
    DERSIMONIAN, R
    LAIRD, N
    [J]. CONTROLLED CLINICAL TRIALS, 1986, 7 (03): : 177 - 188
  • [6] New functions for the matrix metalloproteinases in cancer progression
    Egeblad, M
    Werb, Z
    [J]. NATURE REVIEWS CANCER, 2002, 2 (03) : 161 - 174
  • [7] Bias in meta-analysis detected by a simple, graphical test
    Egger, M
    Smith, GD
    Schneider, M
    Minder, C
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 1997, 315 (7109): : 629 - 634
  • [8] Screening of novel matrix metalloproteinases (MMPs) in human fetal membranes
    Fortunato, SJ
    Menon, R
    [J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2002, 19 (10) : 483 - 486
  • [9] Tissue MMP-2/TIMP-2-complex are better prognostic factors than serum MMP-2, MMP-9 or TIMP-1 in Stage I-III lung carcinoma
    Hoikkala, S.
    Paakko, P.
    Soini, Y.
    Makitaro, R.
    Kinnula, V.
    Turpeenniemi-Hujanen, T.
    [J]. CANCER LETTERS, 2006, 236 (01) : 125 - 132
  • [10] Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development
    Hojilla, CV
    Mohammed, FF
    Khokha, R
    [J]. BRITISH JOURNAL OF CANCER, 2003, 89 (10) : 1817 - 1821
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