L-[3-18F]-α-Methyltyrosine Uptake by Lymph Node Metastasis Is a Predictor of Complete Response to CRT in Esophageal Cancer

被引：0
作者：
Sohda, Makoto [1 ]
Miyazaki, Tatsuya [1 ]
Honjyo, Hiroaki [1 ]
Hara, Keigo [1 ]
Ozawa, Daigo [1 ]
Suzuki, Shigemasa [1 ]
Tanaka, Naritaka [1 ]
Sano, Akihiko [1 ]
Sakai, Makoto [1 ]
Yokobori, Takehiko [1 ]
Nakajima, Masanobu [3 ]
Fukuchi, Minoru [1 ]
Kato, Hiroyuki [3 ]
Higuchi, Tetsuya [2 ]
Tsushima, Yoshito [2 ]
Kuwano, Hiroyuki [1 ]
机构：
[1] Gunma Univ, Grad Sch Med, Dept Gen Surg Sci, Maebashi, Gunma 3718511, Japan
[2] Gunma Univ, Grad Sch Med, Dept Diagnost Radiol & Nucl Med, Maebashi, Gunma 3718511, Japan
[3] Dokkyo Med Univ, Dept Surg Oncol, Mibu, Tochigi, Japan
来源：
ANTICANCER RESEARCH | 2014年 / 34卷 / 12期
关键词：
F-18-FAMT; lymph node metastasis; CRT; esophageal cancer; POSITRON-EMISSION-TOMOGRAPHY; SQUAMOUS-CELL CARCINOMA; DEFINITIVE CHEMORADIOTHERAPY; CHEMORADIATION; RECURRENCE; SURGERY; NUMBER;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: The amino acid positron emission tomography (PET) tracer [F-18]-3-fluoro-alpha-methyltyrosine (F-18-FAMT) is known to be highly specific for malignancies. We evaluated the accumulation of F-18-FDG or F-18-FAMT in lymph nodes (LN) prior to definitive chemoradiotherapy (CRT) for esophageal cancer. Patients and Methods: We retrospectively reviewed 30 patients with esophageal squamous cell carcinoma. All patients received definitive CRT. The relationship between the accumulation of F-18-FDG PET or F-18-FAMT PET in LNs prior to CRT and clinical outcomes was assessed. Results: A correlation was observed between LNs in which most of F-18-FAMT was accumulated and complete response (CR) rate, but was not for F-18-FDG. Additionally, for F-18-FAMT, the CR rate was significantly higher in the LN accumulated lesion <= 1 group than in the LN accumulated lesion >2 group. Discussion: To predict the outcome of definitive CRT in patients with esophageal cancer, it is important to evaluate the LN status.
引用
收藏
页码：7473 / 7477
页数：5
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