Diffusion of Pneumocystis jirovecii in the surrounding air of patients with Pneumocystis colonization: frequency and putative risk factors

被引：14
作者：
Frealle, Emilie [1 ,2 ]
Valade, Sandrine [3 ,4 ]
Guigue, Nicolas [4 ,5 ]
Hamane, Samia [4 ,5 ]
Chabe, Magali [2 ]
Le Gal, Solene [6 ]
Damiani, Celine [7 ,8 ]
Totet, Anne [7 ,8 ]
Aliouat, El Moukhtar [2 ]
Nevez, Gilles [6 ]
Menotti, Jean [4 ,5 ,9 ]
机构：
[1] CHU Lille, Lab Parasitol Mycol, F-59000 Lille, France
[2] Univ Lille, CNRS, UMR 8204, CIIL,Inst Pasteur Lille,CHU Lille,Inserm,U1019, Lille, France
[3] St Louis Univ Hosp, AP HP, Intens Care Unit, Paris, France
[4] Paris Diderot Univ, Sorbonne Paris Cite, Paris, France
[5] St Louis Univ Hosp, AP HP, Lab Parasitol Mycol, Paris, France
[6] Brest Univ Hosp, GEIHP EA 3142, Lab Parasitol Mycol, Brest, France
[7] Amiens Univ Hosp, Lab Parasitol Mycol, Amiens, France
[8] Univ Picardie Jules Verne, Amiens, France
[9] Paris Descartes Univ, Sorbonne Paris Cite, Environm Epidemiol Unit, EA 4064, Paris, France
来源：
MEDICAL MYCOLOGY | 2017年 / 55卷 / 05期
关键词：
Pneumocystis jirovecii; Pneumocystis colonization; air shedding; real-time PCR; mtLSU genotype; F SP. HOMINIS; TRANSPLANT RECIPIENTS; PNEUMONIA; CARINII; TRANSMISSION; INFECTION; CLUSTER;
D O I：
10.1093/mmy/myw113
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
In a prospective bicentric study, Pneumocystis jirovecii excretion and diffusion was explored in air samples collected in the rooms occupied by 17 Pneumocystis-colonized patients. P. jirovecii DNA was detected by real-time PCR in the air collected from 3 patients' rooms (17.6%), with identical genotypes in corresponding clinical and air samples. Pneumocystis DNA was detected for 2/3 patients with autoimmune disease treated with corticosteroids versus 1/6 patients with hematologic disease and 0/5 kidney transplant recipients. These data confirm the possible excretion of the fungus by Pneumocystis-colonized patients and thus bring additional arguments for the prevention of airborne transmission in hospital wards.
引用
收藏
页码：568 / 572
页数：5
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