Shedding Light on NF-κB Functions in Cellular Organelles

被引：17

作者：

Carra, Giovanna ^{[1
]}

Avalle, Lidia ^{[2
]}

Secli, Laura ^{[2
]}

Brancaccio, Mara ^{[2
]}

Morotti, Alessandro ^{[1
]}

机构：

[1] Univ Turin, Dept Clin & Biol Sci, Orbassano, Italy

[2] Univ Turin, Mol Biotechnol Ctr, Dept Mol Biotechnol & Hlth Sci, Turin, Italy

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷

关键词：

NF-kappa B-nuclear factor kappa B; mitochondria; endoplasmic reticulum (ER); lysosome; Golgi; anticancer therapy; NUCLEAR TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE; RNA-POLYMERASE-I; ENDOPLASMIC-RETICULUM; MESENCHYMAL TRANSITION; THERAPEUTIC TARGET; MICE LACKING; APOPTOSIS; INHIBITION; PATHWAY;

D O I：

10.3389/fcell.2022.841646

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

NF-kappa B is diffusely recognized as a transcriptional factor able to modulate the expression of various genes involved in a broad spectrum of cellular functions, including proliferation, survival and migration. NF-kappa B is, however, also acting outside the nucleus and beyond its ability to binds to DNA. NF-kappa B is indeed found to localize inside different cellular organelles, such as mitochondria, endoplasmic reticulum, Golgi and nucleoli, where it acts through different partners in mediating various biological functions. Here, we discuss the relationship linking NF-kappa B to the cellular organelles, and how this crosstalk between cellular organelles and NF-kappa B signalling may be evaluated for anticancer therapies.

引用

页数：9

共 87 条

[31] Shared principles in NF-κB signaling [J].