Adaptive immune response of Vγ2Vδ2 T cells:: a new paradigm

被引：57

作者：

Chen, ZW

Letvin, NL

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, TB Res Unit, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Viral Pathogenesis, Boston, MA 02115 USA

来源：

TRENDS IN IMMUNOLOGY | 2003年 / 24卷 / 04期

关键词：

D O I：

10.1016/S1471-4906(03)00032-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of gammadelta T cells in adaptive immunity remains uncertain. Recent studies have demonstrated that a unique subset of gammadelta T cells in primates can mount adaptive immune responses during mycobacterial infections. This Review discusses notable similarities and differences in adaptive immune responses between non-peptidespecific gammadelta T cells and peptide-specific up T cells, and discusses both the molecular basis for gammadelta T-cell responses and potential functions of these enigmatic cells.

引用

页码：213 / 219

页数：7

共 65 条

[1] T-LYMPHOCYTES WITH GAMMA-DELTA+ V-DELTA-2+ ANTIGEN RECEPTORS ARE PRESENT IN INCREASED PROPORTIONS IN A FRACTION OF PATIENTS WITH TUBERCULOSIS OR WITH SARCOIDOSIS [J].