Immunocytochemical localization of ubiquitin A-52 protein in the mouse inner ear

被引：3

作者：

Kitoh, Ryosuke ^{[1
]}

Oshima, Aki ^{[1
]}

Suzuki, Nobuyoshi ^{[1
]}

Hashimoto, Shigenari ^{[1
]}

Takumi, Yutaka ^{[1
]}

Usami, Shin-ichi ^{[1
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Otorhinolaryngol, Matsumoto, Nagano 3908621, Japan

来源：

NEUROREPORT | 2007年 / 18卷 / 09期

关键词：

immunohistochemistry; inner ear; ion homeostasis; strial marginal cell; ubiquitin A-52; vestibular dark cell;

D O I：

10.1097/WNR.0b013e32813ef147

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ubiquitin A-52 residue ribosomal protein fusion product 1 (UbA52) is a gene highly expressed specifically in the inner ear. Through cellular localization we immunocytochemically investigated its function in the inner ear. In the adult mouse, UbA52 protein was distributed in the strial marginal cells and vestibular dark cells, which regulate the endolymphatic ion homeostasis. In the developing mouse cochlea, no significant staining was observed from birth to postnatal day 3, whereas after postnatal day 6, strong UbA52-immunoreactivities were observed in strial marginal cells. Endolymphatic K+ concentration is elevated between postnatal days 3-8: therefore, our results indicate that UbA52 may have a functional role in regulation of ion secretion in the inner ear.

引用

页码：869 / 873

页数：5

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