Effect of resveratrol on the repair of kidney and brain injuries and its regulation on klotho gene in D-galactose-induced aging mice

被引：17
作者：
Chu, San-Hui [1 ]
Yang, Dan [1 ,3 ]
Wang, Ya-ping [1 ]
Yang, Ran [2 ]
Qu, Lingbo [2 ]
Zeng, Hua-jin [1 ]
机构：
[1] Zhengzhou Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Adv Drug Preparat Technol, Zhengzhou 450001, Peoples R China
[2] Zhengzhou Univ, Henan Joint Int Res Lab Green Construct Funct Mol, Coll Chem, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China
[3] Hubei Univ Arts & Sci, Affiliated Hosp, Xiangyang Cent Hosp, Xiangyang 441021, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2021年 / 40卷
基金：
中国国家自然科学基金;
关键词：
Resveratrol; Kidney; Brain; Repair; Klotho gene; Anti-aging mechanism; LIFE-SPAN EXTENSION; RESTRICTION; ACTIVATORS; MECHANISM; STRESS;
D O I：
10.1016/j.bmcl.2021.127913
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Resveratrol is a natural polyhydroxy trans-stilbene product with many biological activities. One of the most striking biological activities of it is its anti-aging potential. Resveratrol can exhibit anti-aging activity via a variety of signaling pathways, however, the repair effect of it on kidney and brain injury in aging mice induced by D-galactose and its regulation on klotho gene expression have not been reported. Herein, the anti-aging activity of resveratrol and its effect on the repair of kidney and brain injuries in D-galactose-induced aging mice, as well as its regulation of klotho gene expression in these two tissues were investigated. The results indicated that resveratrol could significantly increase the aged cell viability and improve the pathological status of aging mice via inhibiting the formation of malondialdehyde and enhancing the activities of superoxide dismutase and catalase. The histological analysis suggested that resveratrol could remarkably repair the damages of kidney and brain tissues in aging mice. Moreover, PCR and western blot have shown that resveratrol could obviously increase the anti-aging klotho gene expression in the above tissues. The data in this paper further revealed and enriched the anti-aging mechanism of resveratrol, and the methods established in this study can be used as a tool to evaluate the anti-aging activity of drugs to a certain extent.
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页数：8
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