Near-infrared light-activatable polymeric nanoformulations for combined therapy and imaging of cancer

被引：78
作者：
Yue, Xiuli [2 ]
Zhang, Qiang [1 ]
Dai, Zhifei [1 ]
机构：
[1] Peking Univ, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Coll Engn, Coll Pharmaceut, Beijing 100871, Peoples R China
[2] Harbin Inst Technol, Sch Municipal & Environm Engn, Harbin 150080, Heilongjiang, Peoples R China
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2017年 / 115卷
基金：
中国国家自然科学基金;
关键词：
Near infrared polymer; Photothermal therapy; Cancer theranostics; Cancer imaging; Triggered drug release; Combined cancer therapy; SENTINEL LYMPH-NODE; PHOTOTHERMAL COMBINATION THERAPY; FUNCTIONALIZED COPPER SULFIDE; IN-VIVO; POLYPYRROLE NANOPARTICLES; CONJUGATED POLYMER; MESOPOROUS SILICA; DRUG CARRIER; PHOTOACOUSTIC TOMOGRAPHY; CONTRAST AGENT;
D O I：
10.1016/j.addr.2017.04.007
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Near infrared (NIR) light allows deep tissue penetration and high spatial resolution due to the reduced scattering of long-wavelength photons. NIR light-activatable polymer nanoparticles are widely exploited for enhanced cancer imaging (diagnosis) and therapy owing to their superior photostability, photothermal conversion efficiency (or high emission rate), and minimal toxicity to cells and tissues. This review surveys the most recent advances in the synthesis of different NIR-absorbing and emissive polymer nanoformulations, and their applications for cancer imaging, photothermal therapy, theranostics and combination therapy by delivering multiple small molecule chemotherapeutics. Photo-responsive drug delivery systems for NIR light-triggered drug release are also discussed with particular emphasis on their molecular designs and formulations as well as photo-reaction mechanisms. Finally, outlook and challenges are presented regarding potential clinical applications of NIR light-activatable nanoformulations. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：155 / 170
页数：16
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