Rhodium-Catalyzed Asymmetric Synthesis of Spirocarbocycles: Arylboron Reagents as Surrogates of 1,2-Dimetalloarenes

被引：111

作者：

Shintani, Ryo ^{[1
]}

Isobe, Shingo ^{[1
]}

Takeda, Momotaro ^{[1
]}

Hayashi, Tamio ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 22期

关键词：

asymmetric catalysis; boron; chiral diene; rhodium; spirocycles; CHIRAL DIENE LIGANDS; QUATERNARY STEREOGENIC CENTERS; C-H ACTIVATION; ENANTIOSELECTIVE SYNTHESIS; CONJUGATE ADDITION; 1,4-PALLADIUM MIGRATION; STEERING LIGANDS; ARYLATIVE CYCLIZATION; CARBON CENTERS; CONSTRUCTION;

D O I：

10.1002/anie.201000937

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Revolutionary Rh-oad: A rhodium/dienecatalyzed addition of sodium tetraarylborates to alkyne-tethered 2-cydoalken-lones has been developed for the synthesis of splrocarbocycles. The tetraarylborates catalytlcally form two new carbon-carbon bonds. A chlral diene ligand also asymmetrically creates quaternary spirocarbon stereocenters with high enantiomeric purity. © 2010 Wiley-VCH Verlag GmbH & Co. KCaA,.

引用

页码：3795 / 3798

页数：4

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