The Impact of Air Pollution on the Course of Cystic Fibrosis: A Review

被引：7

作者：

Blayac, Marion ^{[1
]}

Coll, Patrice ^{[2
,5
]}

Urbach, Valerie ^{[1
]}

Fanen, Pascale ^{[1
,3
]}

Epaud, Ralph ^{[1
,4
]}

Lanone, Sophie ^{[1
]}

机构：

[1] Univ Paris Est Creteil, INSERM, IMRB, Creteil, France

[2] Univ Paris Cite, Paris, France

[3] Hop Henri Mondor, AP HP, Serv Genet, Creteil, France

[4] Ctr Hosp Intercommunal, Ctr Malad Resp Rares RespiRare, CRCM, Creteil, France

[5] Univ Paris Est Creteil, CNRS, LISA, Paris, France

来源：

FRONTIERS IN PHYSIOLOGY | 2022年 / 13卷

关键词：

cystic fibrosis; air pollution; environmental factors; acute exposure; chronic exposure; CF models; TRANSMEMBRANE CONDUCTANCE REGULATOR; PSEUDOMONAS-AERUGINOSA ACQUISITION; LUNG-FUNCTION DECLINE; PULMONARY EXACERBATIONS; PARTICULATE MATTER; SECONDHAND SMOKE; PASSIVE SMOKING; CELLULAR-RESPONSES; CLINICAL-OUTCOMES; OXIDATIVE STRESS;

D O I：

10.3389/fphys.2022.908230

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Cystic fibrosis (CF) is a lethal and widespread autosomal recessive disorder affecting over 80,000 people worldwide. It is caused by mutations of the CFTR gene, which encodes an epithelial anion channel. CF is characterized by a great phenotypic variability which is currently not fully understood. Although CF is genetically determined, the course of the disease might also depend on multiple other factors. Air pollution, whose effects on health and contribution to respiratory diseases are well established, is one environmental factor suspected to modulate the disease severity and influence the lung phenotype of CF patients. This is of particular interest as pulmonary failure is the primary cause of death in CF. The present review discusses current knowledge on the impact of air pollution on CF pathogenesis and aims to explore the underlying cellular and biological mechanisms involved in these effects.

引用

页数：18

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