Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions

被引：109
作者：
Wong, Sze Yinn [1 ,2 ]
Li, Qing [1 ,2 ]
Veselinovic, Jovana [1 ,2 ]
Kim, Byeong-Su [1 ,2 ]
Klibanov, Alexander M. [2 ,3 ,4 ]
Hammond, Paula T. [1 ,2 ]
机构：
[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[2] MIT, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA
[3] MIT, Dept Chem, Cambridge, MA 02139 USA
[4] MIT, Dept Biol Engn, Cambridge, MA 02139 USA
来源：
BIOMATERIALS | 2010年 / 31卷 / 14期
关键词：
Layer-by-Layer (LbL); Polyelectrolyte multilayer; Microbicidal; Bactericidal; Virucidal; Contact-killing; POLYELECTROLYTE MULTILAYERS; ANTIMICROBIAL ACTIVITY; SURFACE MODIFICATION; THIN-FILMS; IN-VITRO; COATINGS; ANTIBACTERIAL; ADSORPTION; MEMBRANE; CONTACT;
D O I：
10.1016/j.biomaterials.2010.01.119
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this work, we designed contact-killing ionically cross-linked polymeric thin films using Layer-by-Layer (LbL) technology. A polycation, N,N-dodecyl,methyl-polyethylenimine, with microbicidal activity was layered with a polyanion, such as poly(acrylic acid), to create LbL films highly effective against both airborne and waterborne Escherichia coli and Staphylococcus aureus (Gram negative and positive bacteria, respectively), as well as influenza A/WSN (H1N1) virus. The dependence of the microbicidal activity on the pH during and post-assembly of LbL film formation, the nature of the polycation and polyanion, the number of layers in the LbL film, and other experimental variables was investigated quantitatively. (C) 2010 Elsevier Ltd. All rights reserved.
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页码：4079 / 4087
页数：9
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