Impact of host genetic polymorphisms on vaccine induced antibody response

被引：48

作者：

Linnik, Janina E. ^{[1
,2
,3
]}

Egli, Adrian ^{[1
,4
]}

机构：

[1] Univ Basel, Dept Biomed, Appl Microbiol Res, Basel, Switzerland

[2] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Basel, Switzerland

[3] Swiss Inst Bioinformat, Basel, Switzerland

[4] Univ Basel Hosp, Clin Microbiol, CH-4031 Basel, Switzerland

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2016年 / 12卷 / 04期

关键词：

vaccine; genetic polymorphism; SNP; individualized vaccination; GWAS; immune response; antibodies; Influenza; Measles; systems biology; GENOME-WIDE ASSOCIATION; SINGLE-NUCLEOTIDE POLYMORPHISMS; INFLUENZA VACCINATION; CYTOKINE RESPONSES; INTERFERON-ALPHA; HEPATITIS-C; IMMUNITY; SYSTEMS; DISEASE; TUBERCULOSIS;

D O I：

10.1080/21645515.2015.1119345

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Many host- and vaccine-specific factors modulate an antibody response. Host genetic polymorphisms, in particular, modulate the immune response in multiple ways on different scales. This review article describes how information on host genetic polymorphisms and corresponding immune cascades may be used to generate personalized vaccine strategies to optimize the antibody response.

引用

页码：907 / 915

页数：9

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