Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging

被引：79
作者：
Gonos, Efstathios S. [1 ]
Kapetanou, Marianna [1 ,2 ]
Sereikaite, Jolanta [3 ]
Bartosz, Grzegorz [4 ]
Naparlo, Katarzyna [5 ]
Grzesik, Michalina [5 ]
Sadowska-Bartosz, Izabela [5 ]
机构：
[1] Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Athens 11635, Greece
[2] Univ Athens, Dept Biochem & Mol Biol, Fac Biol, Athens 15701, Greece
[3] Vilnius Gediminas Tech Univ, Fac Fundamental Sci, Dept Chem & Bioengn, LT-2040 Vilnius, Lithuania
[4] Univ Lodz, Fac Biol & Environm Protect, Dept Mol Biophys, PL-90236 Lodz, Poland
[5] Univ Rzeszow, Fac Biol & Agr, Dept Analyt Biochem, PL-35601 Rzeszow, Poland
来源：
AGING-US | 2018年 / 10卷 / 05期
关键词：
oxidative stress; carbonylation; nitration; chlorination; proteasome; AMYLOID-BETA-PEPTIDE; MILD COGNITIVE IMPAIRMENT; MYELOPEROXIDASE-DERIVED OXIDANTS; REDOX PROTEOMICS IDENTIFICATION; CHAPERONE-MEDIATED AUTOPHAGY; HUMAN EMBRYONIC FIBROBLASTS; METAL-CATALYZED OXIDATION; BLOOD-SERUM PROTEINS; LIFE-SPAN EXTENSION; ALZHEIMERS-DISEASE;
D O I：
10.18632/aging.101450
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases.
引用
收藏
页码：868 / 901
页数：34
相关论文
共 262 条
  • [1] Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans
    Adachi, H
    Fujiwara, Y
    Ishii, N
    [J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1998, 53 (04): : B240 - B244
  • [2] Oxidative modifications of blood serum proteins in myasthenia gravis
    Adamczyk-Sowa, Monika
    Bieszczad-Bedrejczuk, Edyta
    Galiniak, Sabina
    Rozmilowska, Izabela
    Czytewski, Damian
    Bartosz, Grzegorz
    Sadowska-Bartosz, Izabela
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2017, 305 : 145 - 153
  • [3] Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling
    Adav, Sunil S.
    Sze, Siu Kwan
    [J]. MOLECULAR BRAIN, 2016, 9 : 1 - 22
  • [4] Protein oxidative modifications and replicative senescence of WI-38 human embryonic fibroblasts
    Ahmed, Emad Khairy
    Picot, Cedric R.
    Bulteau, Anne-Laure
    Friguet, Bertrand
    [J]. MOLECULAR MECHANISMS AND MODELS OF AGING, 2007, 1119 : 88 - 96
  • [5] Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism
    Alba Sorolla, Ma
    Jose Rodriguez-Colman, Ma
    Tamarit, Jordi
    Ortega, Zaira
    Lucas, Jose J.
    Ferrer, Isidre
    Ros, Joaquim
    Cabiscol, Elisa
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2010, 49 (04) : 612 - 621
  • [6] Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls
    Aldini, Giancarlo
    Dalle-Donne, Isabella
    Facino, Roberto Maffei
    Milzani, Aldo
    Carini, Marina
    [J]. MEDICINAL RESEARCH REVIEWS, 2007, 27 (06) : 817 - 868
  • [7] Curcumin's Biphasic Hormetic Response on Proteasome Activity and Heat-Shock Protein Synthesis in Human Keratinocytes
    Ali, Rehab E.
    Rattan, Suresh I. S.
    [J]. UNDERSTANDING AND MODULATING AGING, 2006, 1067 : 394 - 399
  • [8] Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor 1
    Allanore, Y
    Borderie, D
    Lemaréchal, H
    Ekindjian, OG
    Kahan, A
    [J]. ARTHRITIS RESEARCH & THERAPY, 2004, 6 (04) : R309 - R314
  • [9] Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways
    Almandoz-Gil, Leire
    Welander, Hedvig
    Ihse, Elisabet
    Khoonsari, Payam Emami
    Musunuri, Sravani
    Lendel, Christofer
    Sigvardson, Jessica
    Karlsson, Mikael
    Ingelsson, Martin
    Kultima, Kim
    Bergstrom, Joakim
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2017, 110 : 421 - 431
  • [10] Peptidyl-prolyl cis/trans-Isomerase A1 (Pin1) Is a Target for Modification by Lipid Electrophiles
    Aluise, Christopher D.
    Rose, Kristie
    Boiani, Mariana
    Reyzer, Michelle L.
    Manna, Joseph D.
    Tallman, Keri
    Porter, Ned A.
    Marnett, Lawrence J.
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2013, 26 (02) : 270 - 279
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