Regioselectivity Control in the Oxidative Formal [3+2] Annulations of Ketoxime Acetates and Tetrohydroisoquinolines

被引：42

作者：

Qu, Zhonghua ^{[1
]}

Zhang, Feng ^{[1
,2
]}

Deng, Guo-Jun ^{[1
]}

Huang, Huawen ^{[1
]}

机构：

[1] Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Minist Educ,Key Lab Environm Friendly Chem & Appl, Xiangtan 411105, Peoples R China

[2] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 20期

基金：

中国国家自然科学基金;

关键词：

IRON-CATALYZED CYCLIZATION; OXIME ACETATES; POLYSUBSTITUTED PYRIDINES; CARBOXYLATES; ALDEHYDES; STRATEGY; OXIDANT; ETHERS;

D O I：

10.1021/acs.orglett.9b02978

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel copper-catalyzed oxidative formal [3 + 2] annulations of ketoxime acetates and tetrohydroisoquinolines for the synthesis of fused pyrazoles and imidazoles has been developed. A broad range of important isoquinoline-fused pyrazole and imidazole products were selectively generated by the key control of oxidant.

引用

页码：8239 / 8243

页数：5

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