Helpers of the cellular gatekeeper-miRNAs dance in P53 network

被引：12

作者：

Shi, Ming ^{[1
]}

Liu, Dan ^{[2
]}

Shen, Beifen ^{[1
]}

Guo, Ning ^{[1
]}

机构：

[1] Inst Basic Med Sci, Dept Mol Immunol, Beijing 100850, Peoples R China

[2] Hebei Med Univ, Dept Pathol, Shijiazhuang 050017, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2010年 / 1805卷 / 02期

基金：

中国国家自然科学基金;

关键词：

p53; MicroRNA; Apoptosis; Cell proliferation; Tumor suppresser; Oncogene; NEURAL STEM-CELL; TUMOR-SUPPRESSOR; SELF-RENEWAL; NEGATIVE REGULATOR; SMALL RNAS; IN-VITRO; C-MYC; MICRORNAS; CANCER; EXPRESSION;

D O I：

10.1016/j.bbcan.2009.12.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent findings position microRNA (miRNAs) as novel key players in regulating expression of protein-coding genes by interfering with the stability and/or translation of specific target mRNAs and in controlling cell proliferation and differentiation by actively functioning in the p53 tumor suppression network. Accumulating evidence reveal the intimate relationship between p53 and miRNAs. P53 regulates the expression of miRNAs at multiple levels. miRNAs influence the post-transcriptional regulation and activities of p53 by invoking a myriad of mechanisms. These findings are unveiling the unknown mechanisms of the p53-mediated biological effects. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：218 / 225

页数：8

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