The Microbead: A 0.009 mm3 Implantable Wireless Neural Stimulator

被引:79
作者
Khalifa, Adam [1 ]
Liu, Yuxin [2 ]
Karimi, Yasha [3 ]
Wang, Qihong [4 ]
Eisape, Adebayo [1 ]
Stanacevic, Milutin [3 ]
Thakor, Nitish [4 ]
Bao, Zhenan [2 ]
Etienne-Cummings, Ralph [1 ]
机构
[1] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA
[2] Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA
[3] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA
[4] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA
关键词
Coils; Implants; Electrodes; Resonant frequency; Wireless communication; Capacitors; Optimization; Free-floating implant; miniaturization; microelectrode design; neural stimulation; wireless power transfer; BRAIN ACTIVITY; DESIGN;
D O I
10.1109/TBCAS.2019.2939014
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Wirelessly powered implants are increasingly being developed to interface with neurons in the brain. They often rely on microelectrode arrays, which are limited by their ability to cover large cortical surface areas and long-term stability because of their physical size and rigid configuration. Yet some clinical and research applications prioritize a distributed neural interface over one that offers high channel count. One solution to make large scale, fully specifiable, electrical stimulation/recording possible, is to disconnect the electrodes from the base, so that they can be arbitrarily placed freely in the nervous system. In this work, a wirelessly powered stimulating implant is miniaturized using a novel electrode integration technique, and its implanted depth maximized using new optimization design methods for the transmitter and receiver coils. The stimulating device is implemented in a 130nm CMOS technology with the following characteristics: 300m 300m 80m size; optimized two-coil inductive link; and integrated circuit, electrodes and coil. The wireless and stimulation capability of the implant is demonstrated in a conductive medium, as well as in-vivo. To the best of our knowledge, the fabricated free-floating miniaturized implant has the best depth-to-volume ratio making it an excellent tool for minimally-invasive distributed neural interface, and thus could eventually complement or replace the rigid arrays that are currently the state-of-the-art in brain set-ups.
引用
收藏
页码:971 / 985
页数:15
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