Antifungal activity of caspofungin in experimental infective endocarditis caused by Candida albicans

被引：0

作者：

Becerra Victorio, Gerardo ^{[1
]}

Brennan Bourdon, Lorena Michele ^{[2
]}

Garcia Benavides, Leonel ^{[3
]}

Huerta-Olvera, Selene G. ^{[4
]}

Plascencia, Arturo ^{[5
]}

Villanueva, Jose ^{[6
]}

Martinez-Lopez, Erika ^{[6
]}

Isidro Hernandez-Canaveral, Ivan ^{[7
]}

机构：

[1] Univ Autonoma Chiapas, Fac Ciencias Quim, Chiapas, Mexico

[2] Comis Protecc Riesgos Sanitarios Estado Jalisco, Guadalajara, Jalisco, Mexico

[3] Univ Guadalajara, Ctr Univ Ciencias Salud, Dept Fisiol, Guadalajara, Jalisco, Mexico

[4] Univ Guadalajara, Ctr Univ Cienega, Dept Ciencias Med & Vida, Ocotlan, Jalisco, Mexico

[5] Hosp Civil Fray Antonio Alcalde, Serv Infectol Pediat, Guadalajara, Jalisco, Mexico

[6] Univ Guadalajara, Ctr Univ Ciencias Salud, Dept Biol & Mol Genom, Guadalajara, Jalisco, Mexico

[7] Univ Guadalajara, Ctr Univ Ciencias Salud, Dept Microbiol & Patol, Guadalajara, Jalisco, Mexico

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2017年 / 112卷 / 05期

关键词：

endocarditis; caspofungin; Candida albicans; liposomal amphotericin B; MANAGEMENT;

D O I：

10.1590/0074-02760160494

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

BACKGROUND Infective endocarditis is a disease characterised by heart valve lesions, which exhibit extracellular matrix proteins that act as a physical barrier to prevent the passage of antimicrobial agents. The genus Candida has acquired clinical importance given that it is increasingly being isolated from cases of nosocomial infections. OBJECTIVE To evaluate the activity of caspofungin compared to that of liposomal amphotericin B against Candida albicans in experimental infective endocarditis. METHODS Wistar rats underwent surgical intervention and infection with strains of C. albicans to develop infective endocarditis. Three groups were formed: the first group was treated with caspofungin, the second with liposomal amphotericin B, and the third received a placebo. In vitro sensitivity was first determined to further evaluate the effect of these treatments on a rat experimental model of endocarditis by semiquantitative culture of fibrinous vegetations and histological analysis. FINDINGS Our semiquantitative culture of growing vegetation showed massive C. albicans colonisation in rats without treatment, whereas rats treated with caspofungin showed significantly reduced colonisation, which was similar to the results obtained with liposomal amphotericin B. CONCLUSIONS The antifungal activity of caspofungin is similar to that of liposomal amphotericin B in an experimental model of infective endocarditis caused by C. albicans.

引用

页码：370 / 375

页数：6

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