Development and characterization of salivary adenoid cystic carcinoma cell line

被引：25
|
作者：
Li, Jie [1 ]
Perlaky, Laszlo [2 ]
Rao, Pulivarthi [2 ]
Weber, Randal S. [3 ]
El-Naggar, Adel K. [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Sect Head & Neck Pathol, Houston, TX 77030 USA
[2] Baylor Coll Med, Texas Childrens Canc & Hematol Ctr, Dept Pediat, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030 USA
来源：
ORAL ONCOLOGY | 2014年 / 50卷 / 10期
关键词：
Adenoid cystic carcinoma; Cell line; Salivary gland tumors; EXTRACELLULAR-MATRIX; CLINICAL-SIGNIFICANCE; CROSS-CONTAMINATION; GLAND TUMORS; EXPRESSION; CANCER; HEAD; NECK; IMMORTALIZATION; TRANSFORMATION;
D O I：
10.1016/j.oraloncology.2014.06.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: To develop in vitro adenoid cystic carcinoma cell line as a surrogate for functional studies. Materials and methods: Cells obtained from a primary ACC of the base of tongue were cultivated in vitro and immortalized with h-TERT. Morphologic, cytogenetic and functional studies were performed. Results: Tumor cells were verified by positive reactions to keratin and smooth muscle actin and phenotypic cellular and nuclear features. In-vitro cell growth and colony formation assay supported their tumor nature. Conclusion: We authenticated an ACC cell line with hybrid epithelial-myoepithelial feature as a resource for functional experimentation. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：991 / 999
页数：9
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