Anthocyanins as Key Phytochemicals Acting for the Prevention of Metabolic Diseases: An Overview

被引:30
作者
Nistor, Madalina [1 ]
Pop, Roxana [1 ]
Daescu, Adela [1 ]
Pintea, Adela [2 ]
Socaciu, Carmen [1 ]
Rugina, Dumitrita [2 ]
机构
[1] Univ Agr Sci & Vet Med, Dept Agr Egineering Sci, Manastur St 3 5, Cluj Napoca 400372, Romania
[2] Univ Agr Sci & Vet Med, Dept Vet Med, Manastur St 3 5, Cluj Napoca 400372, Romania
关键词
absorption; anthocyanins; bioavailability; cancer; cardiovascular diseases; diabetes; inflammatory disorders; neuropathologies; oxidative stress; OXIDATIVE STRESS; RICH EXTRACT; BLACK RICE; RED-WINE; IN-VITRO; BLUEBERRY ANTHOCYANINS; RASPBERRY ANTHOCYANINS; ANTIOXIDANT CAPACITY; PHENOLIC-COMPOUNDS; NATURAL-PRODUCTS;
D O I
10.3390/molecules27134254
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Anthocyanins are water-soluble pigments present in fruits and vegetables, which render them an extensive range of colors. They have a wide distribution in the human diet, are innocuous, and, based on numerous studies, have supposed preventive and therapeutical benefits against chronic affections such as inflammatory, neurological, cardiovascular, digestive disorders, diabetes, and cancer, mostly due to their antioxidant action. Despite their great potential as pharmaceutical applications, they have a rather limited use because of their rather low stability to environmental variations. Their absorption was noticed to occur best in the stomach and small intestine, but the pH fluctuation of the digestive system impacts their rapid degradation. Urine excretion and tissue distribution also occur at low rates. The aim of this review is to highlight the chemical characteristics of anthocyanins and emphasize their weaknesses regarding bioavailability. It also targets to deliver an update on the recent advances in the involvement of anthocyanins in different pathologies with a focus on in vivo, in vitro, animal, and human clinical trials.
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页数:37
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