Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa

被引：61
作者：
Conejo, MC
García, I
Martínez-Martínez, L
Picabea, L
Pascual, A
机构：
[1] Univ Sevilla, Sch Med, Dept Microbiol, E-41080 Seville, Spain
[2] Forens Sci Inst, Seville, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 07期
关键词：
D O I：
10.1128/AAC.47.7.2313-2315.2003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The activities of carbapenems against Pseudomonas aeruginosa decreased in the presence of siliconized latex urinary catheters (SLUCs). This effect was associated with the loss of OprD. The zinc that eluted from SLUCs is responsible for this phenomenon. We have found that zinc exerts a negative effect on the expression of OprD, the porin responsible for carbapenem entry into P. aeruginosa.
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页码：2313 / 2315
页数：3
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