(4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one as a chiral auxiliary for the diastereoselective alkylation of a new iminic glycine derivative:: practical asymmetric synthesis of α-amino acids

被引：27

作者：

Guillena, G ^{[1
]}

Nájera, C ^{[1
]}

机构：

[1] Univ Alicante, Fac Ciencias, Dept Quim Organ, Alicante 03080, Spain

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 07期

关键词：

D O I：

10.1016/S0957-4166(98)00113-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The lithium enolate of enantiomerically pure N-[bis(methylthio)methylene] glycinate 11 derived from (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one reacts with alkyl halides giving the alkylated derivatives 12 with a high degree of control of the diastereoselectivity. These alkylated systems are easily hydrolyzed to the corresponding cx-amino acids, the chiral auxiliary being recovered. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1125 / 1129

页数：5

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