Epigenetic regulation of oligodendrocyte identity

被引：108
作者：
Liu, Jia [1 ]
Casaccia, Patrizia [1 ]
机构：
[1] Mt Sinai Sch Med, Dept Neurosci & Genet & Gen, New York, NY 10029 USA
来源：
TRENDS IN NEUROSCIENCES | 2010年 / 33卷 / 04期
基金：
美国国家卫生研究院;
关键词：
EMBRYONIC STEM-CELLS; HISTONE LYSINE DEMETHYLASES; SMALL-MOLECULE COMPOUNDS; MYELIN-BASIC-PROTEIN; NOVO DNA METHYLATION; GENE-EXPRESSION; TRANSCRIPTION FACTOR; NERVOUS-SYSTEM; PROGENITOR DIFFERENTIATION; METHYLTRANSFERASE ACTIVITY;
D O I：
10.1016/j.tins.2010.01.007
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The interplay of transcription factors and epigenetic modifiers, including histone modifications, DNA methylation and microRNAs during development is essential for the acquisition of specific cell fates. Here, we review the epigenetic "programming" of stem cells into oligodendrocytes, by analyzing three sequential stages of lineage progression. The first transition from pluripotent stem cells to neural precursors is characterized by repression of pluripotency genes and restriction of the lineage potential to the neural fate. The second transition from multipotential precursors to oligodendrocyte progenitors is associated with the progressive loss of plasticity and the repression of neuronal and astrocytic genes. The last step of differentiation of oligodendrocyte progenitors into myelin-forming cells is defined by a model of derepression of myelin genes.
引用
收藏
页码：193 / 201
页数：9
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