Isolation and Antimacrofouling Activity of Indole and Furoquinoline Alkaloids from 'Guatambu' Trees (Aspidosperma australe and Balfourodendron riedelianum)

被引：17

作者：

Perez, Miriam ^{[1
,2
]}

Pis Diez, Cristian M. ^{[3
,4
]}

Belen Valdez, Maria ^{[3
,4
]}

Garcia, Monica ^{[1
]}

Paola, Analia ^{[1
,2
]}

Avigliano, Esteban ^{[5
,6
]}

Palermo, Jorge A. ^{[3
,4
]}

Blustein, Guillermo ^{[1
,7
]}

机构：

[1] Ctr Invest & Desarrollo Tecnol Pinturas CIDEPINT, Calle 52 E-121 & 122,B1900AYB, RA-1900 La Plata, Buenos Aires, Argentina

[2] Univ Nacl La Plata, Fac Ciencias Nat & Museo, Calle 60 & 122,B1900AYB, RA-1900 La Plata, Buenos Aires, Argentina

[3] Univ Buenos Aires, Dept Quim Organ, Fac Ciencias Exactas & Nat, Ciudad Univ,Pabellon 2, RA-1428 Buenos Aires, DF, Argentina

[4] Univ Buenos Aires, CONICET, Unidad Microanal & Metodos Fis Quim Organ UMYMFOR, Ciudad Univ,Pabellon 2, RA-1428 Buenos Aires, DF, Argentina

[5] UBA, IIPA, CONICET, Av Chorroarin 280,C1427CWO, RA-1427 Buenos Aires, DF, Argentina

[6] Fdn Bosques Nat Argentinos, CIAR, Camino Balneario S-N, RA-3125 Villa Bonita, Misiones, Argentina

[7] Univ Nacl La Plata, Fac Ciencias Agr & Forestales, Calle 60 & 119,B1900AYB, RA-1900 La Plata, Buenos Aires, Argentina

来源：

CHEMISTRY & BIODIVERSITY | 2019年 / 16卷 / 11期

关键词：

N-methyltetrahydroellipticine; antifouling; kokusaginine; flindersiamine; indole alkaloids; biological activity; BLUE MUSSEL; ANTIPLASMODIAL ACTIVITY; NATURAL ANTIFOULANTS; TERRESTRIAL PLANTS; METABOLITES; DERIVATIVES; SUBSTANCES; CAPSAICIN; TOXICITY; ACID;

D O I：

10.1002/cbdv.201900349

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work, the antifouling activity of five alkaloids, isolated from trees of the Atlantic rainforest, was studied. The tested alkaloids were olivacine (1), uleine (2) and N-methyltetrahydroellipticine (3) from Aspidosperma australe ('yellow guatambu') and the furoquinoline alkaloids kokusaginine (4) and flindersiamine (5) from Balfourodendron riedelianum ('white guatambu'). All these compounds can be isolated from their natural sources in high yields in a sustainable way. The five compounds were subjected to laboratory tests (attachment test of the mussel Mytilus edulis platensis) and field trials, by incorporation into soluble matrix paints, and 45 days of exposure of the painted panels in the sea. The results show that compound 3 is a very potent antifoulant, and that compounds 4 and 5 are also very active, while compounds 1 and 2 did not show any significant antifouling activity. These results open the way for the development of environmentally friendly antifouling agents, based on abundant and easy-to-purify compounds that can be obtained in a sustainable way.

引用

页数：8

共 48 条

[1] Exploration of structure-antifouling relationships of capsaicin-like compounds that inhibit zebra mussel (Dreissena polymorpha) macrofouling [J].