Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins

被引：37

作者：

Chen, Chi-Jene ^{[1
]}

Ermler, Megan E. ^{[1
]}

Tan, Gene S. ^{[1
]}

Krammer, Florian ^{[1
]}

Palese, Peter ^{[1
,2
]}

Hai, Rong ^{[1
,3
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA

[3] Univ Calif Riverside, Dept Plant Pathol & Microbiol, Riverside, CA 92521 USA

来源：

JOURNAL OF VIROLOGY | 2016年 / 90卷 / 07期

关键词：

MONOCLONAL-ANTIBODY; IN-VIVO; CHALLENGE; MICE; VACCINATION; INFECTION;

D O I：

10.1128/JVI.03060-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.

引用

页码：3789 / 3793

页数：5

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