Suppression by baclofen of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats

被引：82
作者：
Colombo, G
Serra, S
Brunetti, G
Vacca, G
Carai, MAM
Gessa, GL
机构：
[1] Univ Cagliari, Bernard B Brodie Dept Neurosci, CNR, Inst Neurogenet & Neuropharmacol, I-09042 Monserrato, CA, Italy
[2] Neurosci Scarl, I-09123 Cagliari, Italy
来源：
DRUG AND ALCOHOL DEPENDENCE | 2003年 / 70卷 / 01期
关键词：
baclofen; GABA(B) receptor; alcohol deprivation effect (ADE); relapse-like drinking; Sardinian alcohol-preferring (sP) rats;
D O I：
10.1016/S0376-8716(02)00333-2
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Alcohol deprivation effect (ADE), i.e. the transient increase in alcohol intake that takes place in laboratory animals after a period of alcohol deprivation, has been proposed to model alcohol relapses in alcoholics. The present study investigated the effect of the GABA(B) receptor agonist, baclofen, on the development of ADE in selectively bred Sardinian alcohol-preferring (sP) rats. Acute administration of non-sedative doses of baclofen (0, 1, 1.7 and 3 mg/kg, i.p.) resulted in the complete suppression of the extra-amount of alcohol consumed during the first hour of re-access to alcohol after 7 days of deprivation. These results implicate the GABAB receptor in the neural substrate mediating ADE and suggest that baclofen may possess anti-relapse properties. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：105 / 108
页数：4
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