An efficient, cyanide free total synthesis of rosuvastatin calcium

被引：3

作者：

Vempala, Naresh ^{[1
,2
]}

Matta, Balaji ^{[2
]}

Rao, S. Venkateswara ^{[2
]}

Maddirala, Shambabu Joseph ^{[1
]}

Shree, A. Jaya ^{[2
]}

机构：

[1] Aragen Life Sci, 12,Plot 28 A, Hyderabad 500076, Telangana, India

[2] Jawaharlal Nehru Technol Univ Hyderabad, Inst Sci & Technol, Ctr Chem Sci & Technol, Hyderabad 500085, India

来源：

TETRAHEDRON | 2022年 / 111卷

关键词：

Total synthesis; Statins; Rosuvastatin calcium; Wittig reaction; Oxa-michael addition; STEREOSELECTIVE-SYNTHESIS; CHEMOENZYMATIC SYNTHESIS; STATINS; REDUCTION; BLOCKS; ROUTE; PART;

D O I：

10.1016/j.tet.2022.132717

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, efficient, cyanide-free protocol for the total synthesis of rosuvastatin calcium was developed from inexpensive, commercially available D-arabinose; the key steps employed were Wittig reaction followed by oxa-Michael addition. The developed synthetic protocol could be adopted for industrial production of rosuvastatin calcium. (C)& nbsp;2022 Elsevier Ltd. All rights reserved.

引用

页数：8

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