N-Alkylation of amines with alcohols catalyzed by a Cp*Ir complex

被引：266

作者：

Fujita, K ^{[1
]}

Li, ZZ

Ozeki, N

Yamaguchi, R

机构：

[1] Kyoto Univ, Grad Sch Global Environm Studies, Dept Nat Resources, Kyoto 6068501, Japan

[2] Kyoto Univ, Grad Sch Human & Environm Studies, Kyoto 6068501, Japan

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 13期

基金：

日本学术振兴会;

关键词：

iridium catalyst; N-alkylation; hydrogen transfer; amine; alcohol;

D O I：

10.1016/S0040-4039(03)00371-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new effective catalytic system consisting of [Cp*IrCl2](2)/K2CO3 (Cp* = pentamethylcyclopentadienyl) for the N-alkylation of primary amines with alcohols has been developed. As an example, the reaction of aniline with benzyl alcohol in the presence of [Cp*IrCl2](2) (5.0 mol%Ir) and K2CO3 (5.0 mol%) in toluene at 110degreesC for 17 h gave benzylaniline in an isolated yield of 88%. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2687 / 2690

页数：4

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