N-Alkylation of amines with alcohols catalyzed by a Cp*Ir complex

被引：266
作者：
Fujita, K [1 ]
Li, ZZ
Ozeki, N
Yamaguchi, R
机构：
[1] Kyoto Univ, Grad Sch Global Environm Studies, Dept Nat Resources, Kyoto 6068501, Japan
[2] Kyoto Univ, Grad Sch Human & Environm Studies, Kyoto 6068501, Japan
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 13期
基金：
日本学术振兴会;
关键词：
iridium catalyst; N-alkylation; hydrogen transfer; amine; alcohol;
D O I：
10.1016/S0040-4039(03)00371-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new effective catalytic system consisting of [Cp*IrCl2](2)/K2CO3 (Cp* = pentamethylcyclopentadienyl) for the N-alkylation of primary amines with alcohols has been developed. As an example, the reaction of aniline with benzyl alcohol in the presence of [Cp*IrCl2](2) (5.0 mol%Ir) and K2CO3 (5.0 mol%) in toluene at 110degreesC for 17 h gave benzylaniline in an isolated yield of 88%. (C) 2003 Elsevier Science Ltd. All rights reserved.
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页码：2687 / 2690
页数：4
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