Microwave-assisted one-pot synthesis of some new flavonols by modified Algar-Flynn-Oyamada reaction and their antimicrobial activity

被引：14

作者：

Ashok, Dongamanti ^{[1
]}

Kifah, Mohsin Ahmed ^{[1
]}

Lakshmi, Bommidi Vijaya ^{[1
]}

Sarasija, Madderla ^{[2
]}

Adam, Shaik ^{[3
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad 500007, Telangana, India

[2] Satavahana Univ, Dept Chem, Karimnagar 505001, Telangana, India

[3] ANGRAU, Reg Agr Res Stn, Tirupati 517502, Andhra Pradesh, India

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2016年 / 52卷 / 03期

关键词：

3-hydroxy-2-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]-4H-chromen-4-ones; 1-phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde; antimicrobial activity; microwave irradiation; modified Algar-Flynn-Oyamada reaction; BIOLOGICAL EVALUATION; PYRAZOLE; DERIVATIVES; DESIGN; SERIES;

D O I：

10.1007/s10593-016-1852-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of 3-hydroxy-2-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]-4H-chromen-4-ones has been synthesized from substituted 2-hydroxyacetophenones and 1-phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde using NaOH and H2O2 by modified Algar-Flynn-Oyamada reaction under conventional and microwave irradiation conditions. In this method flavonols are synthesized without isolating chalcones in good yields (80-85%). The structures of the compounds were established on the basis of IR, H-1, C-13 NMR and mass spectral and elemental analysis data. The synthesized compounds were screened for their antibacterial and antifungal activities.

引用

页码：172 / 176

页数：5

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