Linezolid Treatment for Intracranial Abscesses Caused by Methicillin-Resistant Staphylococcus Aureus -Two Case Reports

被引:15
作者
Saito, Norihiko [1 ]
Aoki, Kazuya [1 ]
Sakurai, Takatoshi [1 ]
Ito, Keisuke [1 ]
Hayashi, Morito [1 ]
Hirata, Yoko [1 ]
Sato, Kenichiro [1 ]
Harashina, Junichi [1 ]
Akahata, Masaki [1 ]
Iwabuchi, Satoshi [1 ]
机构
[1] Toho Univ, Dept Neurosurg, Ohashi Med Ctr, Meguro Ku, Tokyo 1538515, Japan
关键词
linezolid; methicillin-resistant Staphylococcus aureus; postneurosurgical infection; intracranial infection; vancomycin; NERVOUS-SYSTEM INFECTIONS; RISK-FACTORS; CEREBROSPINAL-FLUID; MENINGITIS; NEUROSURGERY; EPIDERMIDIS;
D O I
10.2176/nmc.50.515
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Two patients were treated for intracranial infections involving methicillin-resistant Staphylococcus a ureus (MRSA). A 30-year-old woman was admitted to our hospital for intracerebral hemorrhage related to arteriovenous malformation. After decompressive craniectomy, the patient developed an epidural abscess. MRSA was isolated from the pus culture. The infection did not improve after intravenous vancomycin (VCM) administration for 15 days. However, after administration of linezolid (LZD) for 14 days, the infection had improved, and the white blood cell count and C-reactive protein values had normalized. A 53-year-old woman had previously undergone 3 operations for craniopharyngioma before the age of 35 years. She was admitted to our hospital with fever and disturbance of consciousness. Magnetic resonance imaging with contrast medium revealed a brain abscess caused by MRSA. After 14 days of intravenous administration of VCM, the infection had not improved and intravenous administration of LZD was initiated. After administration of LZD for 14 days intravenously and 14 days orally, the infection had improved, and the white blood cell count and C-reactive protein values had normalized. VCM is highly effective against MRSA infection, but penetration into the central nervous system (CNS) is poor. LZD has good CNS penetration, so should be considered for secondline antibiotic therapy for VCM-resistant intracranial MRSA infection.
引用
收藏
页码:515 / 517
页数:3
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